J4 ›› 2011, Vol. 37 ›› Issue (1): 72-75.
Previous Articles Next Articles
LI Si-Jie, JIA Hong-Yao, HAN Bing, WU Di, FU Tong
Received:
Online:
Published:
Contact:
Supported by:
中国-加拿大大学合作项目资助课题(Sulcp010#);吉林大学基本科研业务费资助课题(421030170428)
Abstract:
Abstract:Objective To investigate the expression level of STAT3 protein in human breast cancer tissues and corresponding adjacent normal mammary tissues,and clarify the relationship between STAT3 expression and clinical characters in patients with breast cancer. Methods The expressions of STAT3 protein in 67 human breast cancer tissues and the corresponding adjacent normal mammary tissues were detected by immunohistochemical technique.The expressions of STAT3 protein in patients with different clinicopathological parameters were analyzed. Results The expression rate of STAT3 protein in 67 human breast cancer tissues was 62.69% (42/67) which was significantly higher than that in normal mammary tissues (25.37%,P<0.001). The expression level of STAT3 had no correlation with the age,tumor size and histological type in patients with breast cancer(P>0.05),but the expression of STAT3 protein was positively correlated with clinical stage,lymph node metastasis and survival time in patients with breast cancer. The mean survival time of the patients with high expression of STAT3 protein was shorter than that of the patients with low expression of STAT3 protein(P<0.05). Conclusion STAT3 protein over-expression may play a promotion role in the tumorigenesis and development of breast cancer,and may be an important prognostic factor in breast cancer.
Key words: breast neoplasms;signal transducers and activators of transcription;prognosis;protein expression;immunohistochemistry
CLC Number:
LI Si-Jie, JIA Hong-Yao, HAN Bing, WU Di, FU Tong. Expression of STAT3 protein in human breast cancer tissue and its clinical significances[J].J4, 2011, 37(1): 72-75.
0 / / Recommend
Add to citation manager EndNote|Reference Manager|ProCite|BibTeX|RefWorks
URL: http://xuebao.jlu.edu.cn/yxb/EN/
http://xuebao.jlu.edu.cn/yxb/EN/Y2011/V37/I1/72
Cited