Abstract:

Abstract:Objective To explore the effect of donepezil hydrochloride on learning and memory function of normal   under age rats,and provide experimental  basis for  clinical application of donepezil hydrochloride.Methods Fourty Wistar rats just away from galactic were divided into control group(n=20) and donepezil hydrochlorid group(n=20),donepezil hydrochloride was given to the rats in donepezil hydrochloride group（0.45 mg·kg^-1，8 weeks）， the  effects of  donepezil hydrochloride on space discrimination ability and passive avoidance ability of normal  under age rats were detected with Morris water maze and Step-down   behavior test.Results Compared with control group,the latency,distance,average speed and starting angle of rats treated by donepezil hydrochloride did not change significantly  from the first day to the  sixth day，the time in platform， time in platform quadrant，times passing platform， distance in platform / total distance×100%  and average speed also did not change significantly in the seventh day  in the Morris water maze （P>0.05）; the error times of  rats treated by donepezil hydrochloride  did not decrease in the first day and in the second day,the latency did not prolong in the second day in Step-down  behavior test（P>0.05） .Conclusion Donepezil hydrochloride do not improve the  learning and memory function  of    normal under age rats.

Key words: donepezil hydrochloride;learning;memory;rats,Wistar