Abstract:

Objective To observe the expressions of Snail and E-cadherin in laryngeal squamous cell carcinoma(LSCC) tissues and normal squamous epidermis tissues near cancer,and to clarify the relationship with the occurrence and development of LSCC.Methods Streptavidin peroxidase(S-P method) immunohistochemistry staining was used to detect the expressions of Snail and E-cadherin in 46 samples of LSCC and 46 samples of normal squamous epidermis near cancer.The relationship between the expressions of Snail and E-cadherin and the clinical pathological characteristics were analyzed.And the relevance of the expressions of Snail and E-cadherin in LSCC was also analyzed.Results ① The positive rates of Snail expressions in LSCC and  normal squamous epidermis near cancer were 69.57%(32/46) and 36.96%(17/46). The expression of Snail in LSCC was significantly higher than that in normal squamous epidermis near cancer (P<0.05).There was  significant correlation between the expression of Snail in LSCC and the differentiation and cervical lymph node matastasis (P<0.05).②The positive rates of E-cadherin expressions in LSCC and normal squamous epidermis near cancer were 47.83％(22/46)and 78.30％(36/46).The expression of E-cadherin in LSCC was significantly lower than that in normal squamous epidermis near cancer (P<0.05).There was significant correlation between the expression of E-cadherin in LSCC with the T stage,clinical stage,cervical lymph node matastasis and differentiation (P<0.05).③The expression of Snail in LSCC tissues was negatively correlated with the expression of E-cadherin (r=－0.569 0,P<0.01).Conclusion The expressions of Snail and E-cadherin  may be  associated with the occurrence and development of LSCC,and they could be used as the parameters which predict the  malignant degree  and  prognosis of LSCC.

Key words: Snail；E-cadherin；laryngeal squamous cell carcinoma； immunohistochemistry；epithelial-mesenchymal transition