Abstract:

Objective To study the expressions of heat shock protein 70(HSP 70) and its upstream regulation factor HSF1 in laryngeal papilloma and vocal leukoplakia  and clarify their action in the genesis of human laryngeal  carcinoma.Methods The expressions of HSP70 and HSF1 proteins were detected by  immunohistochemical method in 6 specimens with vocal leukoplakia (vocal leukoplakia group),6 specimens with laryngeal papilloma (laryngeal papilloma group ) and 7 specimens of vocal cord polyp (control group).Results The expressions of HSP70 and HSF1 in laryngeal papilloma and vocal leukoplakia  were higher than that in vocal cord polyp,the differences were significant(P<0.05 or P<0.01),the expressions of HSP and HSF1  in vocal leukoplakia  were the highest.Linear regression analysis of HSP70 protein and HSF1 expressions in vocal cord polyp,laryngeal papilloma and vocal leukoplakia  showed positive linear correlation (r=0.867,P<0.01 ).Conclusion The overexpression of HSP70 and HSF1 protein in vocal leukoplakia  may contribute to the genesis of human laryngeal  carcinoma.HSP70 and HSF1 may be used as indicators for early diagnosis of laryngeal carcinoma.

Key words: heat shock protein 70;HSF1;laryngeal papilloma;vocal leukoplakia