Abstract:

Abstract:Objective To observe the clinical efficacy of Self-prepared Softening Liver and Eliminating Fat Decoction in treatment of  non-alcoholic steatohepatitis (NASH).Methods 172 patients with NASH,according to the willingness of patients,were divided into western medicine treatment group (n=50),Chinese medicine treatment group (n=56),and combined treatment group with  Chinese and western medicine (n=66).The patients in Western medicine treatment group were treated with oral western medicine for protecting the liver，reducing enzyme and lowering blood lipids,in traditional Chinese medicine group with Self-prepared Softening Liver and Eliminating Fat Decoction,in combined treatment group with western medicine  combined with Chinese medicine,and lasted for 3 months.The liver   function,serum lipids,liver image were observed.Results In combined treatment group,50 cases were cured,12 cases were effective,4 cases were ineffective,the cure rate was 75.8%,the total effective rate was 93.9%; in  Chinese medicine treatment group,38 cases were cured,15 cases were effective,3 cases were ineffective,the cure rate was 67.9%,the total effective rate was 94.6%; in western medicine group,26 cases were cured,17 cases were effective,7 cases were ineffective,the cure rate was 52.0%,the total effective rate was 86.0%.In Chinese medicine treatment group and combined treatment group  the cure rates and the total effective rates were  significantly higher than those in  western medicine group (P<0.05 or  P<0.01); the cure rate in combined treatment group was higher than that in Chinese medicine treatment group (P<0.05); the difference in effective rate between   combined treatment group and Chinese treatment group had no significant difference (P> 0.05).The serum ALT,AST,and GGT levels after treatment in three groups were lower than before   treatment (P<0.01); the ALT,AST,and GGT levels in  Chinese medicine group and combined treatment group were lower than those in western medicine group (P<0.05 or   P<0.01); the ALT,AST,and GGT levels after treatment in combined treatment group and Chinese medicine group had no significant difference (P> 0.05).The serum TG and TC after treatment in three groups were decreased compared with before treatment,there were significant differences (P<0.01); the TG and TC levels in Chinese medicine treatment group and combined treatment group were lower than those in  western medicine group (P<0.05 or P<0.01); there were no significant difference in the   TG  and TC levels between Chinese medicine treatment group and combined treatment group(P>0.05).In the course of treatment,some short-term gastrointestinal side effects occurred in western medicine group,but Chinese medicine treatment group and combined treatment group had no obvious adverse reactions.Conclusion  Self-prepared Softening Liver and Eliminating Fat Decoction has the exact effect on NASH and has no adverse reactions; Self-prepared Softening Liver and Eliminating Fat Decoction combined with western medicine can significantly improve the clinical cure rate of NASH,and  reduce the gastrointestinal tract reaction caused by western medicine.

Key words: non-alcoholic steatohepatitis, Self-prepared Softening Liver and Eliminating Fat Decoction, efficacy evaluation