肥胖青少年阻塞性睡眠呼吸暂停综合征患者上气道临界压的变化及其临床意义

doi:10.13481/j.1671-587x.20150520

Abstract

Abstract:

Objective To observe the changes of pharyngeal critical pressure (Pcrit) in the obese adolescents with obstructive sleep apnea syndrome (OSAS),and to investigate the role of Pcrit in the pathogenesis of OSAS in the adolescents. Methods According to the results from polysomnography and body mass index (BMI) measurements,the subjects were divided into obese OSAS group (n=16),obese control group (n=18),and lean control group (n=17).On the base of polysomnography monitoring,the slope of pressure-flow curve and Pcrit were observed by pressure-flow relationship technology.Then the relationship between Pcrit and apnea hypopnea index (AHI) was analyzed. Results The slope of pressure-flow curve and Pcrit of patients in obese OSAS group were significantly higher than those in obese control group and lean control group (P<0.01);the Pcrit of objects in obese control group was lower than that in lean control group (P<0.05).In obese OSAS group,the positive correlation was found between the slope of pressure-flow curve and AHI (r=0.789,P=0.005),as well as Pcrit and AHI (r=0.654,P=0.032). Conclusion The increase of Pcrit is one of the reasons for upper airway obstruction in the obese adolescents with OSAS.To maintain Pcrit is important for the obese adolescents without OSAS to protect the upper airway from occlusion.

Key words: adolescent, obstructive sleep apnea syndrome, pharyngeal critical pressure

CLC Number:

R562

YUAN Haibo, ZHANG Zhengjiao, ZHANG Yanqiu, PENG Liping, HUA Shucheng. Changes of pharyngeal critical pressure in obese adolescents with obstructive sleep apnea syndrome and its clinical significance[J].Journal of Jilin University Medicine Edition, 2015, 41(05): 990-993.

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Changes of pharyngeal critical pressure in obese adolescents with obstructive sleep apnea syndrome and its clinical significance

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