脂蛋白(a)水平与VH-IVUS检测冠脉粥样硬化斑块成分的关联性分析

doi:10.13481/j.1671-587x.20160123

Abstract

Abstract:

Objective: To analyze the characteristics of atherosclerotic plaques in the patients with coronary heart disease (CHD)by virtual histology intravascular ultrasound (VH-IVUS),and to discuss their correlations with lipoprotein (a) ［Lp(a)］.Methods: 54 patients with chest pain were divided into non ST elevation acute coronary syndromes (NSTEACS)group (n=18),stable angina pectoris (SAP)group(n=21)and control group (n=15)according to the symptoms and coronary angiography results of the patients.The serum biochemical indexes were measured in all patients.In 39 CHD patients,culprit lesions were detected with VH-IVUS to investigate the characteristics of atherosclerotic plaques and their relevance with Lp(a). Results:The levels of Lp(a),low density lipoprotein (LDL)and hypersensitive C reactive protein (hs-CRP)of the patients in NSTEACS and SAP groups were significantly higher than those in control group (P< 0.05);the levels of serum Lp(a),hs-CRP and LDL in NSTEACS group were higher than those in SAP group(P<0.05).The incidence of necrotic tissue (NC),fiber lipid (FF),and vulnerable plaque (TCFA)in lesion patches of the patients in SAP group were significantly decreased(P<0.05)compared with NSTEACS group.The plasma Lp(a) was positively associated with NC,FF,TCFA serum and hs-CRP (r =0.411,r =0.312,r =0.318,r =0.309,P<0.05).Conclusion: The vulnerability of plaques in the NSTEACS patients in creases with the increase of Lp(a) level:Plasma Lp(a) is a sensitive index for evaluating the plaque vulnerability.

Key words: lipoprotein (a), virtual histology, intravascular ultrasound, vulnerable plaques

CLC Number:

R541.4

ZHANG Yichun, XU Yan, GU Hepin. Analysis on correlation between lipoprotein (a)and VH-IVUS examination of atherosclerotic plaque in patients with CHD[J].Journal of Jilin University Medicine Edition, 2016, 42(01): 115-119.

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Analysis on correlation between lipoprotein (a)and VH-IVUS examination of atherosclerotic plaque in patients with CHD

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