Abstract:

Abstract:Objective To investigate the effects of  mangiferin hydrasis granule（MHG） on blood glucose,blood fat and insulin in Goto-Kakizaki （GK）model rats and their mechanisms.Methods Thirty-six male GK rats were randomly divided into control group, rosiglitazone group and MHG （20.0，40.0 mg/kg）groups （n=9）.The rats were administered by intragastric administration for 4 weeks .The change of  body weight was observed and the blood glucose，blood fat ，insulin in serum were detected.Results The body weight rats in control group was significantly decreased，and continuely droped during aderministration;compared with control group，the body weights of rats in rosiglitazone group and MHG 20.0,40.0 mg?kg-1 groups were increased(P<0.05).Compared with control group , the contents of blood glucose in rosiglitazone group and MHG（40.0 mg?kg-1）group were decreased（P<0.05 ）.There was no significant difference of the  insulin content between various groups（P＞0.05）.Compared with control group,the contents of triglyceride（TG）and total cholesterol（TC）in rosiglitazone group were decreased（P<0.05）;the content of total cholesterol（TC）in MHG（40.0 mg/kg-1 ）group was decreased（P<0.05）.Conclusion MHG can reduce the risk of diabetes mellitus by down-regulating the contents of blood glucose and blood fat in GK rats．

Key words: mangiferin hydrasis granule；diabetes mellitus；blood glucose;blood fat；insulin;GK rats