Abstract:

Objective
To explore the CLDN6 expressions in ovarian cancer,liver cancer and meningioma tissues and clinical significances,and clarify its effects in the occurrence and development of cancer.Methods The expressions of CLDN6 in 36 ovarian cancer tissues,30 liver cancer tissues and 29 invasion meningioma tissues were detected by SP immunohistochemical staining,at the same time,26 benign neoplasm of ovarian tissues,19 normal hepatic tissues and 29 non-invasion meningioma tissues were used as control.Results The positive expression rates of CLDN6 in ovarian cancer tissues and  benign neoplasm of ovarian tissues were  69.44% and 34.62%,there was significant difference between them（P<0.05）；the expression positive rates of CLDN6   in liver cancer tissues and normal hepatic tissues were 73.33% and 26.31%,there was significant difference between then(P<0.05);the positive expression rates of CLDN6 in  invasion meningioma tissues and  non-invasion meningioma tissues were  10.34% and 65.51%，there was also significant difference（P<0.05）.Conclusion The expression of CLDN6 is up-regulated in ovarian cancer and liver cancer tissues,and down-regulated in invasion meningioma tissues. It may have positive or negative regulatory effect on different cancers by destroying compose of tight junctions.

Key words: neoplasms；tight junctions；CLDN6；immunohistochemisty