Sixty rats were randomly divided into control group， model group， low， medium and high doses of GTW groups， and there were 12 rats in each group. Adenine was used to induce the CKD rat models. The rats in low， medium and high doses of GTW groups were given 3.0， 6.0 and 9.0 mg·kg^－1 GTW by gavage， while the rats in control group and model group were given the same volume of normal saline. The levels of blood urea nitrogen（BUN） and serum creatinine（Scr） of the rats in various groups were measured after 4 weeks of administration. HE and Masson staining were used to observe the pathological changes of the kidney tissue and the changes of fibrosis of the rats in various groups. The levels of endothelin-1 （ET-1）， nitric oxide （NO）， angiotensinⅡ（AngⅡ），tumor necrosis factor-α （TNF-α），interleukin （IL-6） and transforming growth factor β1（TGF-β1） in serum of the rats in various groups were measured by ELISA.

Compared with control group， the levels of BUN， Scr， ET-1， AngⅡ， TNF-α， IL-6 and TGF-β1 in serum of the rats in model group were significantly increased （P<0.05）， while the NO level was significantly decreased （P<0.05）， and the degree of renal fibrosis was significantly increased （P<0.05）. Compared with model group， the levels of BUN， Scr， ET-1， AngⅡ， TNF-α， IL-6 and TGF-β1 in serum of the rats in low， medium and high doses of GTW groups were significantly decreased （P<0.05）， while the NO levels were significantly increased （P<0.05）， and the degrees of renal fibrosis were significantly decreased （P<0.05）. The results of HE staining showed that the glomeruli and tubules in the kidney tissue of the rats in control group were intact and the cells arranged orderly； in model group， edema， balloon adhesion and inflammatory cell infiltration occurred in glomeruli and tubules of the rats； the kidney tissue of the rats in low， medium and high doses of GTW groups showed different degrees of edema and inflammatory cell infiltration， and the damage degrees were less than that in model group.

GTW can improve vascular endothelial injury in the CKD rats by down-regulating the ET-1 and AngⅡ levels and up-regulating the NO levels；GTW was improvement effect on the vascular endothelial injury of the CKD rats.