猪肾脏异种移植的研究进展Research progress in pig kidney xenotransplantation

doi:10.13481/j.1671-587X.20210332

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R617

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References

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Year	Edited gene of donor pig	Longest survival time of transplanted kidney（t/d）	Reference
1989	wt	23	[40]
2004	hCD55	90	[33]
2005	GGTA1-KO	83	[30]
2015	GalT-KO/CD46/CD55/EPCR/ TFPI/CD47 GalT-KO/CD46/TBM	260	[38]
2018	GGTA1-KO/hCD55	499	[41]

Drug	Mechanism	Side effect	Reference
CTLA-4 Ig	Block the CD80/86 costimulatory pathway and disable T cells	Colitis	[44]
Anti-CD154 m Ab	Block the CD40/CD154 pathway, and cause inactivation of T cells	Thrombotic vascular disease	[43]
Anti-CD40 m Ab	Block the CD40/CD154 pathway, and cause inactivation of T cells	Toxic to the liver Autoimmune diabetes in mouse models	[45]
Anti-thymocyte globulin	Regulate the expression of lymphocyte surface antigen and inhibit T cell activation	Hemolytic anemia Thrombocytopenia	[46]
Anti-CD3/CD7 immunotoxins	Induce T cell consumption and inhibit TCR activation	Thrombocytopenia Microvascular disease	[47]

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