Journal of Jilin University(Medicine Edition) ›› 2021, Vol. 47 ›› Issue (6): 1407-1414.doi: 10.13481/j.1671-587X.20210609
• Research in basic medicine • Previous Articles Next Articles
Xueying ZHANG,Lianwen ZHENG,Yinggang ZOU,Zhenhuan ZHOU()
Received:
2021-05-06
Online:
2021-11-28
Published:
2021-12-14
Contact:
Zhenhuan ZHOU
E-mail:1063103487@qq.com
CLC Number:
Xueying ZHANG,Lianwen ZHENG,Yinggang ZOU,Zhenhuan ZHOU. Effect of bisphenol A exposure on mRNA molecule expression profile in ovarian tissue of prepubertal female rats[J].Journal of Jilin University(Medicine Edition), 2021, 47(6): 1407-1414.
Tab.1
Body weights of rats in various groups after BPA exposure"
Group | Body weight | |||
---|---|---|---|---|
PND28 | PND32 | PND36 | PND41 | |
Control | 100.43±0.75 | 121.80±1.11 | 141.34±1.69 | 156.11±3.20 |
BPA | ||||
Low dose | 103.43±2.01 | 126.88±2.91 | 146.98±3.22 | 157.03±4.04 |
Middle dose | 101.79±1.36 | 122.61±1.79 | 143.44±2.27 | 157.85±3.08 |
High dose | 98.95±1.20 | 121.79±1.37 | 144.01±1.77 | 157.16±2.84 |
Tab.3
Expression levels of Hapln3, Nr4a1, Arc, Ccl2, Ccn5, Egr2,and Rab33a mRNA in ovarian tissue of rats in two groups (n=3,x±s)"
Group | Hapln3 | Nr4a1 | Arc | Ccl2 | Ccn5 | Egr2 | Rab33a |
---|---|---|---|---|---|---|---|
Control | 1.014 7±0.117 3 | 1.014 7±0.117 3 | 1.014 7±0.117 3 | 1.014 7±0.117 3 | 1.014 7±0.117 3 | 1.014 7±0.117 3 | 1.014 7±0.117 3 |
High dose of BPA | 0.078 5±0.014 4* | 0.078 5±0.014 4* | 0.078 5±0.014 4* | 0.078 5±0.014 4* | 0.078 5±0.014 4* | 0.078 5±0.014 4* | 0.078 5±0.014 4* |
Tab.4
KEGG enrichment analysis of all differential expression genes"
KEGG Pathway Classification | Related Genes |
---|---|
Cytokine-cytokine receptor interaction | Inhba, Ccl2 |
Apoptosis - multiple species | Pmaip1 |
Aldosterone synthesis and secretion | Nr4a1 |
NOD-like receptor signaling pathway | Ccl2 |
p53 signaling pathway | Pmaip1 |
TGF-beta signaling pathway | Inhba |
TNF signaling pathway | Ccl2 |
Signaling pathways regulating pluripotency of stem cells | Inhba |
Apoptosis | Pmaip1 |
Chemokine signaling pathway | Ccl2 |
MAPK signaling pathway | Nr4a1 |
PI3K-Akt signaling pathway | Nr4a1 |
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