Journal of Jilin University(Medicine Edition) ›› 2022, Vol. 48 ›› Issue (3): 744-754.doi: 10.13481/j.1671-587X.20220324
• Research in basic medicine • Previous Articles
Ming LI,Qiuting WANG,Shan CHEN,Huifang SHI()
Received:
2021-08-20
Online:
2022-05-28
Published:
2022-06-21
Contact:
Huifang SHI
E-mail:touming_915717@163.com
CLC Number:
Ming LI,Qiuting WANG,Shan CHEN,Huifang SHI. Improvement effect of p38 MAPK inhibitor on chronic obstructive pulmonary disease injury in mice through inhibiting cell pyrotosis mediated by NLRP3 pathway[J].Journal of Jilin University(Medicine Edition), 2022, 48(3): 744-754.
Tab. 1
Number of inflammatory cells in BALF of mice in various groups"
Group | No. of total leukocytes | No. of neutrophils | No. of macrophages | No. of lymphocytes |
---|---|---|---|---|
Control | 7.41±1.35 | 2.79±0.33 | 3.51±0.48 | 5.66±1.49 |
SB | 6.82±1.26 | 2.84±0.64 | 4.02±0.41 | 6.17±1.01 |
COPD | 42.19±5.49* | 12.61±2.38* | 17.91±2.18* | 19.84±3.18* |
COPD+SB | 17.11±3.02*△ | 8.73±1.25*△ | 12.58±1.26*△ | 14.55±2.90*△ |
F | 36.106 | 19.187 | 31.439 | 28.215 |
P | <0.01 | <0.01 | <0.01 | <0.01 |
Tab. 2
Levels of inflammatory factors in BALF of mice in various groups [n=6,x±s,ρB /(ng·L-1)]"
Group | TNF-α | IL-6 | IL-1β | IL-18 |
---|---|---|---|---|
Control | 82.16±15.09 | 77.41±13.33 | 14.51±4.28 | 20.03±3.05 |
SB | 79.31±20.11 | 70.79±14.26 | 15.09±3.17 | 19.85±2.71 |
COPD | 331.28±49.30** | 376.21±51.48** | 235.66±34.20** | 84.62±16.15* |
COPD+SB | 259.17±32.85*△ | 265.11±14.72*△ | 91.83±27.57**△△ | 62.05±11.42*△ |
F | 20.055 | 44.682 | 24.273 | 39.095 |
P | <0.01 | <0.01 | <0.01 | <0.01 |
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