Abstract:

Objective To investigate the pregnancy outcomes of fresh embryo transfer in the same infertile patients receiving the GnRH antagonist （GnRH-ant） program and the GnRH agonist （GnRH-a） program for ovulation， and to provide basis for the selection of ovulation induction program. Methods Using retrospectively research method， the clinical data and laboratory examination data of 74 patients （148 cycles in total） received GnRH-a program and GnRH-ant program treatment for ovulation within 2 years were collected. The effects of ovulation promotion， embryo development and clinical outcome of fresh cycle transplantation were analyzed. Results The ovulation induction detection results showed that compared with GnRH-a group， the total dose and time of gonadotropin （Gn） use， and endometrial thickness of the patients in GnRH-ant group were decreased （P<0.05 or P<0.01）； the level of luteinizing hormone （LH） on the human chorionic gonadotropin （HCG） day was significantly increased （P<0.01）；there were no significant differences in the number of oocytes retrieved and the levels of progesterone（P） and estradiol（E2） on the HCG day （P>0.05）. The embryo status detection results showed that compared with GnRH-a group，the 2 pronucleus（2PN） rate， abnormal fertilization rate，2PN cleavage rate， available blastocyst formation rate and high quality blastocyst formation rate in GnRH-ant group were increased， but there were no significant differences （P>0.05），while the good embryo rate and available embryo rate in GnRH-ant group were significantly increased （P<0.05）.In clinical pregnancy outcome， there were no significant differences in the number of embryos transferred， ectopic pregnancy rate， abortion rate， implantation rate and clinical pregnancy rate in two groups （P>0.05）. Conclusion GnRH-ant program could be a more suitable plan for ovulation due to the higher good embryo rate， avaliable embryo rate， lower Gn dose and shorter Gn using time compared with GnRH-a program.

Key words: Gonadotropin releasing hormone antagonist program, Gonadotropin releasing hormone agonist program, Embryo transfer, In vitro fertilization