脐带间充质干细胞在女性生殖系统疾病治疗中应用的研究进展

doi:10.13481/j.1671-587X.20250331

Abstract

Abstract:

Female reproductive system diseases， such as premature ovarian insufficiency （POI）， premature ovarian failure （POF）， polycystic ovary syndrome （PCOS）， intrauterine adhesions （IUA）， ulterus scar diverticulum， salpingitis， and tubal obstruction， may induce infertility， severely impacting patients’ physical and mental health and quality of life. Currently， the umbilical cord mesenchymal stem cells （UCMSCs） have emerged as a research focus in gynecological and obstetric fields， demonstrating significant therapeutic potential for female reproductive system disorders. UCMSCs secrete various cytokines， activate relevant signaling pathways and key molecules， reduce inflammation mediators and oxidative stress， and prevent excessive cellular damage and apoptosis， thereby achieving therapeutic effects. In recent years， extensive studies have explored the therapeutic effects of UCMSCs on female reproductive system diseases. This article review the current in vitro and in vivo research progress in UCMSCs for treating female reproductive system diseases， aiming to provide the novel strategies and directions for future research and clinical applications.

Key words: Umbilical cord mesenchymal stem cells, Female reproductive system diseases, Infertility, Tissue repair and regeneration, Regenerative medicine, Stem cell technology

CLC Number:

R711.7

Mingming JIN,Ran SUN,Minghui FAN,Lu GAO,Minjia SHENG. Research progress in application of umbilical cord mesenchymal stem cells in treatment of female reproductive system diseases[J].Journal of Jilin University(Medicine Edition), 2025, 51(3): 839-847.

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Research progress in application of umbilical cord mesenchymal stem cells in treatment of female reproductive system diseases

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