细胞分裂周期蛋白6与肿瘤发生发展关系的研究进展

doi:10.13481/j.1671-587X.20260327

Abstract

Abstract:

Cell division cycle protein 6 （CDC6） is a member of the adenosine triphosphatase （ATPase） associated with diverse cellular activities（AAA+ATPase） family associated with a variety of cellular activities， which possesses ATPase activity and is highly conserved in eukaryotes. CDC6 is a key component of the pre-replication complex （pre-RC） and participates in the initiation of DNA replication. Meanwhile， it is also involved in regulating the S/M cycle checkpoints and modulating cell mitosis. CDC6 is abnormally expressed in a variety of malignant tumors and regarded as an oncogene. Its dysregulated expression leads to abnormal DNA replication and DNA damage， thereby affecting the occurrence and development of tumors. Moreover， a variety of drugs and regulatory factors have been confirmed to be able to inhibit the expression of CDC6 and block the growth of tumor cells. Therefore， CDC6 is a potential therapeutic target and prognostic biomarker. Based on the domestic and international research achievements of CDC6， this paper reviewed the structure and inhibitors of CDC6 protein， as well as its pathogenesis in glioma， prostate cancer（PCa）， breast cancer and many other tumors， so as to provide references for the treatment of malignant tumors.

Key words: Cell division cycle protein 6, Glioma, Prostate neoplasms, Breast neoplasms, Inhibitor, Therapeutic target

CLC Number:

R730.2

Lina ZHANG,Zhesi MENG,Long BA,Jun MENG. Research progress in relationship between cell division cycle protein 6 and occurrence and development of tumor[J].Journal of Jilin University(Medicine Edition), 2026, 52(3): 847-853.

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Research progress in relationship between cell division cycle protein 6 and occurrence and development of tumor

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