缺氧诱导因子在胶质瘤细胞上皮-间质转化过程中对细胞迁移和侵袭影响的研究进展

doi:10.13481/j.1671-587X.20250432

Abstract

Abstract:

Epithelial-mesenchymal transition （EMT） is a critical process in the development of various cancers， including glioma. In glioma cells， the activation of hypoxia-inducible factors （HIFs） can influence the occurrence of EMT， promoting cell migration and invasion. This review aims to explore the role of HIF in the EMT process of glioma cells， focusing on its impact on cell migration and invasion， including regulation of angiogenesis， metabolic reprogramming， glycolysis， and the immune system in the tumor microenvironment. Additionally， this review summarizes the role of HIF in EMT-related signaling pathways， such as Wnt/β-catenin （β-catenin）， Notch， and transforming growth factor-β （TGF-β）， and provides new insights and directions for further understanding the mechanisms of HIF in the EMT process of glioma cells.

Key words: Hypoxia-inducible factor, Glioma, Epithelial-mesenchymal transition, Cell migration, Cell invasion

CLC Number:

R739.41

Zhongjun SHEN,Yao ZHAO,Mingbo JIA,Liyan ZHAO. Research progress in effects of hypoxia-inducible factors on cell migration and invasion during epithelial-mesenchymal transition in glioma cells[J].Journal of Jilin University(Medicine Edition), 2025, 51(4): 1145-1154.

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Research progress in effects of hypoxia-inducible factors on cell migration and invasion during epithelial-mesenchymal transition in glioma cells

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