Abstract:

Objective To explore the effect of calcium and vitamin D fortified drinking supplementation on the growthdevelopment of bone tissue in children,and to clarify the necessity of nutrients supplementation in childhood. Methods 294 students  (147 males,147 females) in   the grade one and two  in primary school aged between 6-8 years old  were selected and  were randomly divided in to two groups:intervention group(n=174) and control group(n=120).The students in intervention group and control group were from the same school but different classes,who had a similar social and economic background.The students in intervention group drank 250 mL drink every morning;and the students in control group maintained their daily diet without the supplement drinks.The intervention time was one year.After the intervention,the calcium metabolism,bone mineral composition (BMC),bone mineral density (BMD),bone area (BA) and so on were observed before and after  intervention in two groups.Results Before  intervention,the indexes including the calcium metabolism,BMC,BMD,BA and so on had no statistical significances between two groups(P>0.05).After  intervention,the 25-(OH)　 D levels and osteocalcin levels of boys and girls in intervention group were significantly higher than those in control group (P<0.05);the total amount of lower limbs and femur,BMC of greater trochanter of femur,BA of femur and BMD of lower limb and greater trochanter of  boys in intervention group were significantly higher than those in control group (P<0.05), the BMC of bones of upper limbs and BMD of girls in intervention group were significantly higher than those in control group (P<0.05).Conclusion Supplement of drinks fortified with calcium and vitamin D could promote the growth development of children’s bone tissue.

Key words: calcium；vitamin D； bone tissue;bone development