Abstract:

Abstract:Objective
To study the protective effect of zinc sulfate on liver injury of diabetic rats induced by STZ and explore its mechanism. Methods Fifty  male Wistar rats were randomly divided into five groups: normal diet (NC) group, high fat diet (FC) group, diabetes (DM) group, Zn before the intervention of diabetes (ZnDM) group, Zn after the intervention of diabetes (DMZn) group. The rats in Zn groups were fed with Zn ions (Zn2+) 15　mg?kg-1?d-1 by giving ZnSO4 solution daily by gavage, the others were fed with distilled water by gavage. Eight weeks after STZ injection, the serum was collected to detect the function of liver, AST and ALT, and liver was taken for the measurement of liver index, SOD, MDA, and GSH-Px. Results  Compared with DM group, Zn intervention could significantly reduce the liver index (P<0.05); the levels of AST and ALT in serum were decreased mildl (P>0.05); the level of MDA in liver tissues was markedly decreased and the levels of SOD and GSH-Px in liver tissue were significantly improved (P<0.05)； the levels of MDA and SOD in liver tissues had significant differences between the two groups of Zn intervention (P<0.05). Conclusion Exogenous zinc sulfate can decrease the liver index of diabetic rats, and make the liver function better. The mechanism of the protection of Zn may be related to the strengthening of anti-oxidation.  

Key words:  diabetes mellitus, hyperlipidemia, zinc, liver, anti-oxidation