Abstract:

Objective To study the effects of formaldehyde on the level of microelements in mouse liver and blood and explore the microelements as biomarker in injury induced by formaldehyde.Methods The mice were randomly divided into control,low（1/40LD50）,moderate（1/20LD50） and high（1/10LD50） dose groups exposed to formaldehyde by inhalation(n=20),two hours per day for three and six weeks,and than the contents of Cu,Fe,Zn and Mn in mouse liver and blood were measured.Results  The contents of Fe,Zn and Mn in liver in high dose group three weeks after exposure and the contents of Fe and Zn in liver in high dose group six weeks after exposure were significantly lower than those in control group(P<0.05);the contents of Mn and Zn in blood in high dose group three weeks after exposure were significantly lower than those in control group(P<0.05);while six weeks after exposure,the contents of Fe and Zn in blood in moderate and high dose groups were significantly lower than those in control group(P<0.05);and the content of Cu had no significant change in each group.
Conclusion Formaldehyde might decrease the contents of Fe,Zn and Mn in mouse liver and blood,and the Fe,Zn and Mn could be used as biomarkers in injury induced by formaldehyde.

Key words:  formaldehyde;microelements;biomarker