吉林大学学报(工学版) ›› 2018, Vol. 48 ›› Issue (4): 1206-1213.doi: 10.13229/j.cnki.jdxbgxb20170521

Previous Articles     Next Articles

Human exogenous plant miRNA cross-kingdom regulatory modeling based on high-throughout data

ZHANG Hao1,2, ZHAN Meng-ping2,3, GUO Liu-xiang2,3, LI Zhi4, LIU Yuan-ning1,2, ZHANG Chun-he1,2, CHANG Hao-wu1,2, WANG Zhi-qiang1,2   

  1. .College of Computer Science and Technology, Jilin University, Changchun 130012, China;
    2.Symbol Computation and Knowledge Engineering of Ministry of Education,Jilin University,Changchun 130012,China;
    3.College of Software, Jilin University, Changchun 130012,China;
    4.College of Applied Technique, Changchun University of Science and Technology, Changchun 130022, China
  • Received:2017-04-27 Online:2018-07-01 Published:2018-07-01

RICH HTML

1   

PDF (PC)

340

Abstract: Exogenous miRNAs are cross-kingdom regulatory in bacteria and viruses, but whether exogenous plant miRNAs are stable in the human body and are involved in cross-kingdom regulation is still controversial. Only by cross-border modeling on the basis of a comprehensive analysis of the human high-throughput miRNA data, and design of effective biological experiments, the human exogenous plant miRNA presence, access pathways and regulatory role can be revealed. In this paper, high-throughput sequencing data based on human serum were used as the study objective and were analyzed by bio-calculation method. The possible human exogenous plant miRNAs were screened by using the RNA data of human and plant as the reference group. Based on the principle of miRNA regulatory mechanism, the possible target genes of plant miRNAs interfering with human mRNA were obtained. A network model of plant miRNA-human mRNA was constructed to analyze possible cross-kingdom regulation. Nine core modules were excavated by constructing a plant-human cross-kingdom regulation model. The results show that exogenous plant miRNAs are involved in the regulation of biological process such as human amine metabolism, alcohol metabolism and fatty acid metabolism.

Key words: artificial intelligence, high throughput data, exogenous plant miRNA, cross-species regulation

CLC Number: 

  • TP399
[1] Nelson P, Kiriakidou M, Sharma A.The miRNA world: small is mighty[J]. Trends in Biochemical Sciences, 2003, 28(10): 534-540.
[2] Bushati N, Cohen S M. miRNA functions[J]. Annual Review of Cell and Development Biology, 2007, 23: 175-205.
[3] Xiao Chang-chun, Klaus Rajewsky. miRNA control in the immune system: basic inciples[J]. Cell,2009,1(9):26-36.
[4] Liang G F, Zhu Y L, Sun B, et al.Assessing the survival of exogenous plant miRNA in mice[J]. Food Science & Nutrition, 2014, 2(4): 380-388.
[5] Pastrello C, Tsay M, McQuaid R, et al. Circulating plant miRNAs can regulate human gene expression in vitro[J]. Scientific Reports, 2016,6:32773.
[6] Zhou Z, Li X, Liu J, et al.Honeysuckle-encoded atypical miRNA2911 directly targets influenza A viruses[J]. Cell Research, 2015, 25(1): 39-49.
[7] Zhang L, Hou D.Exogenous plant MIR168a specifically targets mammalian LDLRAP1: evidence of cross-kingdom regulation by miRNA[J]. Cell Research, 2012, 22(1): 107-126.
[8] Di Leva G, Garofalo M, Croce C M.Micro RNAs in Cancer[J].Annu Rev Pathol,2014, 9:287-314.
[9] Grolmusz V.A note on the pagerank of undirected graphs[J]. Information Processing Letters, 2015, 115(6): 633-634.
[10] Lü L, Zhang Y C,Yeung C H,et al.Leaders in social networks,the delicious case[J]. PloS One,2011,6(6):1-9.
[11] Licatalosi D D, Darnell R B.RNA processing and its regulation: global insights into biological networks[J]. Nature Reviews Genetics,2010,11(1):75.
[1] DONG Sa, LIU Da-you, OUYANG Ruo-chuan, ZHU Yun-gang, LI Li-na. Logistic regression classification in networked data with heterophily based on second-order Markov assumption [J]. Journal of Jilin University(Engineering and Technology Edition), 2018, 48(5): 1571-1577.
[2] GU Hai-jun, TIAN Ya-qian, CUI Ying. Intelligent interactive agent for home service [J]. Journal of Jilin University(Engineering and Technology Edition), 2018, 48(5): 1578-1585.
[3] WANG Xu, OUYANG Ji-hong, CHEN Gui-fen. Measurement of graph similarity based on vertical dimension sequence dynamic time warping method [J]. 吉林大学学报(工学版), 2018, 48(4): 1199-1205.
[4] HUANG Lan, JI Lin-ying, YAO Gang, ZHAI Rui-feng, BAI Tian. Construction of disease-symptom semantic net for misdiagnosis prompt [J]. 吉林大学学报(工学版), 2018, 48(3): 859-865.
[5] LI Xiong-fei, FENG Ting-ting, LUO Shi, ZHANG Xiao-li. Automatic music composition algorithm based on recurrent neural network [J]. 吉林大学学报(工学版), 2018, 48(3): 866-873.
[6] LIU Jie, ZHANG Ping, GAO Wan-fu. Feature selection method based on conditional relevance [J]. 吉林大学学报(工学版), 2018, 48(3): 874-881.
[7] WANG Xu, OUYANG Ji-hong, CHEN Gui-fen. Heuristic algorithm of all common subsequences of multiple sequences for measuring multiple graphs similarity [J]. 吉林大学学报(工学版), 2018, 48(2): 526-532.
[8] YANG Xin, XIA Si-jun, LIU Dong-xue, FEI Shu-min, HU Yin-ji. Target tracking based on improved accelerated gradient under tracking-learning-detection framework [J]. 吉林大学学报(工学版), 2018, 48(2): 533-538.
[9] LIU Xue-juan, YUAN Jia-bin, XU Juan, DUAN Bo-jia. Quantum k-means algorithm [J]. 吉林大学学报(工学版), 2018, 48(2): 539-544.
[10] QU Hui-yan, ZHAO Wei, QIN Ai-hong. A fast collision detection algorithm based on optimization operator [J]. 吉林大学学报(工学版), 2017, 47(5): 1598-1603.
[11] LI Jia-fei, SUN Xiao-yu. Clustering method for uncertain data based on spectral decomposition [J]. 吉林大学学报(工学版), 2017, 47(5): 1604-1611.
[12] SHAO Ke-yong, CHEN Feng, WANG Ting-ting, WANG Ji-chi, ZHOU Li-peng. Full state based adaptive control of fractional order chaotic system without equilibrium point [J]. 吉林大学学报(工学版), 2017, 47(4): 1225-1230.
[13] WANG Sheng-sheng, WANG Chuang-feng, GU Fang-ming. Spatio-temporal reasoning for OPRA direction relation network [J]. 吉林大学学报(工学版), 2017, 47(4): 1238-1243.
[14] MA Miao, LI Yi-bin. Multi-level image sequences and convolutional neural networks based human action recognition method [J]. 吉林大学学报(工学版), 2017, 47(4): 1244-1252.
[15] ZHOU Bing-hai, PENG Tao. Optimal schedule of just-in-time part distribution for mixed-model assembly lines [J]. 吉林大学学报(工学版), 2017, 47(4): 1253-1261.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] PENG Qi-yuan,XU Jin,ZHENG Sheng-bao,SHAO Yi-ming,DENG Tian-min. Effect of road pavement material change at tunnel entrance and exit on vehicle operation and optimization of transition location[J]. 吉林大学学报(工学版), 2009, 39(06): 1497 -1503 .
[2] WANG Xin,JIANG Ji-hai. Regenerative braking control strategy for wheel drive hydraulic hybrid vehicle[J]. 吉林大学学报(工学版), 2009, 39(06): 1544 -1549 .
[3] WU Jian,DONG Hui-juan,ZHANG Song-bai,ZHANG Guang-yu. Novel primary series matching scheme for piezoelectric ultrasonic transducer[J]. 吉林大学学报(工学版), 2009, 39(06): 1641 -1645 .
[4] ZHENG Wen-Zhong, WAN Fu-Xiong, LI Shi-Guang. Mechanical performance of reinforced concrete slabs strengthened with CFRP sheets bonded with an inorganic adhesive after fire[J]. 吉林大学学报(工学版), 2010, 40(05): 1244 -1249 .
[5] LIU Song-shan, WANG Qing-nian, WANG Wei-hua, LIN Xin. Influence of inertial mass on damping and amplitude-frequency characteristic of regenerative suspension[J]. 吉林大学学报(工学版), 2013, 43(03): 557 -563 .
[6] CHU Liang, WANG Yan-bo, QI Fu-wei, ZHANG Yong-sheng. Control method of inlet valves for brake pressure fine regulation[J]. 吉林大学学报(工学版), 2013, 43(03): 564 -570 .
[7] LI Jing, WANG Zi-han, YU Chun-xian, HAN Zuo-yue, SUN Bo-hua. Design of control system to follow vehicle state with HIL test beach[J]. 吉林大学学报(工学版), 2013, 43(03): 577 -583 .
[8] HU Xing-jun, LI Teng-fei, WANG Jing-yu, YANG Bo, GUO Peng, LIAO Lei. Numerical simulation of the influence of rear-end panels on the wake flow field of a heavy-duty truck[J]. 吉林大学学报(工学版), 2013, 43(03): 595 -601 .
[9] WANG Tong-jian, CHEN Jin-shi, ZHAO Feng, ZHAO Qing-bo, LIU Xin-hui, YUAN Hua-shan. Mechanical-hydraulic co-simulation and experiment of full hydraulic steering systems[J]. 吉林大学学报(工学版), 2013, 43(03): 607 -612 .
[10] ZHANG Chun-qin, JIANG Gui-yan, WU Zheng-yan. Factors influencing motor vehicle travel departure time choice behavior[J]. 吉林大学学报(工学版), 2013, 43(03): 626 -632 .
Copyright © Journal of Jilin University(Engineering and Technology Edition), All Rights Reserved.
Tel: +86-431-85095297　Fax: +86-431-85094074　E-mail: xbgxb@jlu.edu.cn
Powered by Beijing Magtech Co. Ltd