红蓝光照射联合西黄胶囊治疗面部中重度痤疮疗效及安全性评价

doi:10.13481/j.1671-587x.20160432

吉林大学学报(医学版) ›› 2016, Vol. 42 ›› Issue (04): 803-806.doi: 10.13481/j.1671-587x.20160432

红蓝光照射联合西黄胶囊治疗面部中重度痤疮疗效及安全性评价

李劲然¹, 王连有², 王震¹, 孙铭徽¹, 朱明姬¹, 贾玉玺¹

1. 吉林大学中日联谊医院皮肤科, 吉林长春 130033;
2. 吉林大学中日联谊医院病理科, 吉林长春 130033

收稿日期:2016-04-19 发布日期:2016-07-20
通讯作者: 朱明姬,教授,硕士研究生导师(Tel:0431-84995523,E-mail:zhumingji33@163.com);贾玉玺,主治医师(Tel:0431-84995523,E-mail:jiayuxi2006@126.com) E-mail:zhumingji33@163.com;jiayuxi2006@126.com
作者简介:李劲然(1991-),男,吉林省长春市人,在读医学硕士,主要从事皮肤病的基础与临床方面的研究。
基金资助:
吉林省科技厅社会发展处基金资助课题（20090471）

Evaluation on curative efficacy and safety of red-blue light irradiation combined with Xihuang Capsules in treatment of moderate to severe acne vulgaris

LI Jinran¹, WANG Lianyou², WANG Zhen¹, SUN Minghui¹, ZHU Mingji¹, JIA Yuxi¹

1. Department of Dermatology, China-Japan Union Hospital, Jilin University, Changchun 130033, China;
2. Department of Pathology, China-Japan Union Hospital, Changchun 130033, China

Received:2016-04-19 Published:2016-07-20

摘要/Abstract

摘要：

目的：采用红蓝光照射联合西黄胶囊治疗面部中重度痤疮，并评价其疗效及安全性。方法：80例中重度痤疮患者随机分为西黄胶囊组（对照组）和红蓝光照射联合西黄胶囊组（观察组），每组40例。对照组患者口服西黄胶囊，每次1.5g，每日2次；观察组患者采用红蓝光照射治疗，每次20min，每周2次，同时口服西黄胶囊，每次1.5g，每日2次；治疗时间均为4周。治疗后2和4周各随访1次，观察患者皮损变化情况及不良反应发生情况，比较其疗效。结果：治疗2周后，观察组总有效率为67.5%，对照组为52.5%，2组总有效率比较差异无统计学意义（P > 0.05），但观察组患者炎性皮损和非炎性皮损消退数目明显多于对照组（P=0.002和P=0.005）；治疗4周后，观察组总有效率为85.0%，对照组总有效率为65.0%，观察组疗效明显优于对照组（P < 0.05），且观察组患者炎性皮损和非炎性皮损消退数目均明显多于对照组（P=0.01和 P=0.001）。治疗期间2组患者均未见严重不良反应，观察组仅有2例患者在红光照射治疗后有轻度头痛及恶心症状，下调照射剂量后症状消失。结论：红蓝光照射联合西黄胶囊治疗面部中重度痤疮具有见效快、疗效好、安全性高的优势，值得在临床上推广应用。

关键词: 红蓝光, 西黄胶囊, 痤疮, 寻常, 疗效

Abstract:

Objective: To evaluate the clinical therapeutic efficacy and safety of red-blue light irradiation combined with Xihuang Capsules in the treatment of moderate to severe acne vulgaris. Methods: Eighty patients with moderate to severe acne vulgaris were randomly divided into Xihuang Capsules group (control group) and red-blue light irradiation combined with Xihuang Capsules group(observation group). The patients in observation group were treated with red-blue light irradiation (20 min biw,4 weeks)combined with Xihuang Capsules (1.5 g bid,4 weeks), while the patients in control group took only Xihuang Capsules orally (1.5 g bid, 4 weeks), The changes of skin lesions and adverse reactions were observed and the curative efficacies were compared at 2 or 4 weeks after treatment. Results: After 2- week- treatment, the total effective rate in observation group was 67.5% while the total effective rate in control group was 52.5%,there was no statistically significant difference between two groups (P > 0.05). The regression number of inflammatory and non-inflammatory skin lesions in observation group was significantly higher than that in control group (P < 0.05). After 4- week- treatment, the total effective rate in observation group was significantly higher than that in control group (85.0% vs 65.0% ),and the difference was statistically significant (P < 0.05);the regression number of inflammatory and non-inflammatory skin lesions in observation group was significantly higher than that in control group (P < 0.05).During the treatment, there were no severe adverse reactions in two groups. Mild headache and nausea occurred in observation group after red-blue light irradiation, but the above symptoms disappeared after reducing the irradiation dose. Conclusion: Red-blue light irradiation combined with Xihuang Capsules in the treatment of moderate to severe acne is proved to be a significantly effective and safe method,and it is worth to be promoted in clinic.

Key words: red -blue light, Xihuang Capsules, acne vulgaris, curative efficacy

中图分类号:

R758.733

李劲然, 王连有, 王震, 孙铭徽, 朱明姬, 贾玉玺. 红蓝光照射联合西黄胶囊治疗面部中重度痤疮疗效及安全性评价[J]. 吉林大学学报(医学版), 2016, 42(04): 803-806.

LI Jinran, WANG Lianyou, WANG Zhen, SUN Minghui, ZHU Mingji, JIA Yuxi. Evaluation on curative efficacy and safety of red-blue light irradiation combined with Xihuang Capsules in treatment of moderate to severe acne vulgaris[J]. Journal of Jilin University Medicine Edition, 2016, 42(04): 803-806.

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红蓝光照射联合西黄胶囊治疗面部中重度痤疮疗效及安全性评价

Evaluation on curative efficacy and safety of red-blue light irradiation combined with Xihuang Capsules in treatment of moderate to severe acne vulgaris

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