PTEN在特发性肺纤维化中作用的研究进展

doi:10.13481/j.1671-587x.20190138

摘要/Abstract

摘要： 第10号染色体同源丢失性磷酸酶-张力蛋白基因（PTEN）是一个改变较为广泛且与肿瘤发生有密切关联的抑癌基因，而PTEN蛋白是具有丝/苏氨酸及酪氨酸活性的双特异性磷酸酶活性的蛋白。近年来多项研究表明PTEN活性或表达水平的改变参与肺纤维化的发生发展。PTEN可能通过调控上皮间质转化、成纤维细胞表型转化和自噬等过程参与调节肺纤维化。本文就PTEN在肺纤维化中表达异常及PTEN在肺纤维化中作用的研究进行综述。

关键词: 第10号染色体同源丢失性磷酸酶-张力蛋白基因, 肺纤维化, 成纤维细胞, 表型转化, 上皮间质转化, 细胞自噬

中图分类号:

R563.9

武丹, 曾林祥. PTEN在特发性肺纤维化中作用的研究进展[J]. 吉林大学学报(医学版), 2019, 45(01): 202-205.

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