绝经后女性促卵泡激素水平与血脂指标的关系

doi:10.13481/j.1671-587x.20200125

摘要/Abstract

摘要： 目的：探讨绝经后女性促卵泡激素（FSH）水平与各项血脂指标的关系，为评估绝经后女性的血脂异常风险提供依据。方法：选取绝经1年以上女性129例，依据FSH中位数将研究对象分为低水平FSH组（FSH<57.6IU·L^-1）和高水平FSH组（FSH≥57.6 IU·L^-1）。收集受试者身高、体质量、体质量指数（BMI）、年龄、绝经年龄、绝经年限、吸烟史和基础疾病史等资料，采用统一方法检测血清总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、非高密度脂蛋白胆固醇（non-HDL-C）、雌二醇（E2）、FSH、静脉空腹血糖（FBG）和血尿酸（SUA）等指标。应用多因素Logistic回归分析FSH水平与血脂异常的关系。结果：纳入本研究的绝经后女性受试者平均年龄为（61.22±7.30）岁，绝经年龄为（49.97±4.00）岁，绝经年限为（11.16±7.98）年。绝经后女性受试者并发血脂异常的比例为65.9%（85/129），低水平FSH组和高水平FSH组受试者并发血脂异常的比例比较差异无统计学意义（P>0.05）。低水平FSH组受试者的TG水平高于高水平FSH组（P<0.01），而HDL-C水平低于高水平FSH组（P<0.01），2组间TC、LDL-C和non-HDL-C水平比较差异无统计学意义（均P>0.05）。多因素Logistic回归分析，校正E2水平、年龄、绝经年限、高血压病史、糖尿病史、有无脂肪肝和BMI等级因素后，FSH水平与TG升高（≥2.3 mmol·L^-1）呈负相关关系（P<0.05），FSH每升高10 IU·L^-1则TG升高的风险下降29.5%（95% CI：3.6%~48.5%），而FSH水平与TC升高（≥6.2 mmol·L^-1）、LDL-C升高（≥4.1 mmol·L^-1）、HDL-C降低（<1.0 mmol·L^-1）和non-HDL-C升高（≥4.9 mmol·L^-1）无明显相关性（均P>0.05）。结论：绝经后女性的FSH水平与TG升高呈明显负相关关系，提示低水平FSH是绝经后女性血脂异常的危险因素。

关键词: 心血管疾病, 促卵泡激素, 血脂, 绝经

Abstract: Objective: To explore the relationships between the follicle-stimulating hormone (FSH) level and the lipid profiles in the post-menopausal women, and to provide evidence for assessing the risk of dyslipidemia in the post-menopausal women. Methods: A total of 129 women with menopause for more than 1 year were selected as the subjects and divided into low FSH group(FSH<57.6 IU·L^-1) and high FSH group (FSH ≥ 57.6 IU·L^-1) according to the median of FSH. The data including height, weight, body mass index(BMI), age, menopausal age, duration of menopause, history of smoking, chronic diseases history of the subjects were collected; the serum total cholesterol(TC), triglyceride(TG), low density lipoprotein cholesterol(LDL-C), high density lipoprotein cholesterol(HDL-C), non-density lipoprotein cholesterol(non-HDL-C), estradiol(E2), FSH, fasting blood glucose, serum uric acid of the subjects were detected with the same method. Multivariate Logistic regression analysis was applied to analyze the relationship between the FSH level and dyslipidemia. Results: The average age of the post-menopausal women was (61.22±7.30) years, the age of menopause was (49.97±4.00) years, and the duration of menopause was (11.16±7.98) years. The proportion of post-menopausal women with dyslipidemia was 65.9%(85/129), and there was no significant difference between two groups(P>0.05).Compared with high FSH group, the TG level of the subjects in low FSH group was increased(P<0.01) and the HDL-C level was decreased(P<0.01). There were no significant differences in the TC, LDL-C and non-HDL-C levels between two groups. The Logistic regression analysis showed that after adjusting the E2 level, age, duration of menopause, hypertension history, diabetes history, fatty liver and the BMI grade, FSH level had a negative correlation with TG increase(≥ 2.3mmol·L^-1)(P<0.05). Each 10-unit increase in FSH was associated with a 29.5% lower risk of elevated TG (95%CI: 3.5%-48.5%). FSH was not significantly associated with the elevated TC(≥ 6.2mmol·L^-1), elevated LDL-C(≥ 4.1mmol·L^-1), decreased HDL-C(<1.0 mmol·L^-1) and elevated non-HDL-C. Conclusion: The FSH level is negatively associated with elevated TG inthe post-menopausal women, suggesting that low FSH appears to be a risk factor of dyslipidemia in the post-menopausal women.

Key words: cardiovascular disease, follicle-stimulating hormone, lipid profiles, post-menopause

中图分类号:

R589.2

王宁, 郑延坤, 秦明照. 绝经后女性促卵泡激素水平与血脂指标的关系[J]. 吉林大学学报(医学版), 2020, 46(01): 144-148.

WANG Ning, ZHENG Yankun, QIN Mingzhao. Relationships between follicle-stimulating hormone level and lipid profiles in post-menopausal women[J]. Journal of Jilin University(Medicine Edition), 2020, 46(01): 144-148.

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