GRIM-19与泌尿男生殖系肿瘤发生发展关系的研究进展

doi:10.13481/j.1671-587x.20200437

摘要/Abstract

摘要： 维甲酸和干扰素诱导的死亡相关基因19（GRIM-19）是线粒体膜呼吸链烟酰胺腺嘌呤二核苷酸（NADH）脱氢酶复合物（Ⅰ）的亚基，参与细胞能量代谢，并能够通过负调控信号转导及转录活化因子3（STAT3）发挥抑癌作用。GRIM-19作为抑癌基因，其表达水平在前列腺癌（PCa）组织中明显降低，与存活素（Survivin）、STAT3及特定microRNA相互作用共同调控PCa细胞的增殖、凋亡、迁移和侵袭；在肾癌（RCC）组织中GRIM-19表达水平明显降低，与RCC的病理分级有关联，影响STAT3转录活性及表达水平，发挥抑制细胞增殖、迁移、侵袭和促进细胞凋亡的作用；在多数中国人膀胱癌（BC）组织中GRIM-19表达水平明显降低且与STAT3表达呈负相关关系，并可能与BC的病理分级、临床分期、转移情况和顺铂类化疗药物抵抗有关联。GRIM-19还可能与肾盂癌、肾血管平滑肌脂肪瘤和肾母细胞瘤等有关联。GRIM-19在多数泌尿男生殖系肿瘤组织中低表达，参与肿瘤的发生发展，但目前尚无相关综述，故本文作者针对GRIM-19在泌尿男生殖系肿瘤中的研究进展作一综述。

中图分类号:

R737

秦家轩, 邢金春. GRIM-19与泌尿男生殖系肿瘤发生发展关系的研究进展[J]. 吉林大学学报(医学版), 2020, 46(04): 894-898.

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