关键词: 移植, 树突细胞, 免疫耐受, 移植, 同种

Abstract: Objective To induce the immune tolerance of recipient to donor trachea pretreated with immunosuppressor. Methods Twenty adult dogs were used, 4 dogs were donors, the others were recipients. The donor dogs were killed and all tracheas were divided into 16 segments. The 2 donor dogs with 8 tracheal segments pretreated by immunosuppressor （CTX 750 mg and MPED 2 g） were used as experimental group, the other 2 donor dogs with 8 tracheal segments without immunosuppressor pretreatment as control group. After the tracheal segments were embedded with omentum in the recipient peritoneal cavity for 3 weeks, all tracheal segments were taken out to evaluate the scale of immune reaction pathologically. Results The normal histological construction was kept in 7 tracheal segments except 1 segment with severe immune rejection in the experimental group. 3 segments with mild rejection, other 3 segments with moderate rejection and another 2 tracheal segments with severe rejection were found in the control group. There was no significant difference between the two groups (P>0.05). Conclusion The pretreatment of donor with immunosuppressor can induce recipient immune tolerance for the canine tracheal allotransplantation.

Key words: transplantation, dendritic cell, immune tolerance, transplantation, homologous