关键词: 代谢, 糖基化终产物, 高级, 代谢, 脂质代谢紊乱

Abstract: Objective To discuss the relationship between advanced glycation end produts (AGEs) and dyslipidemia and the onset of diabetic retinopathy (DR). Methods The serum AGEs and lipids levels were examined in 35 patients with type Ⅱ diabetes complicated with DR,31 patients with type Ⅱ diabetes without DR (NDR) and 16 normal subjects.Results ①The serum AGEs levels in DR group and NDR group were significantly higher than that in normal group (P<0.05). The serum AGEs level in DR group was higher than that in NDR group (P<0.05), but the difference was not significant. ②The serum LDL-C level in NDR group was remarkably higher compared with normal group (P<0.05), while the serum HDL-C and APOA1 levels in NDR group were significantly decreased compared with normal group (P<0.05). In DR group, the serum TCH,TG, and LDL-C levels were higher than those in normal group notably (P<0.05). ③The serum TCH, HDL-C, and LDL-C levels in DR group were significantly higher than those in NDR group (P<0.05). ④Linear correlative analysis showed that the serum AGEs level was positively related with the serum TCH, TG, LDL-C, and APOB levels（r values were 0.705, 0.51, 0.60,　and 0.60, respectively）. Conclusion The generation and accumulation of AGEs, dyslipidemia, as well as the interaction of them are important risk factors for the onset of DR in type Ⅱ diabetic patients. Strict control of blood glucose level and correction of dyslipidemia should be carried out simultaneously, so that the onset and progression of DR can be postponed and controlled more effectly.

Key words: metabolism, glycosylation end products。advanced, dyslipidemia