关键词: 药理学, 心力衰竭, 血流动力学, 戊巴比妥, 类似物和衍生物, 去乙酰毛花甙

Abstract: Objective To study the effects of Aralosides (As) on cardiac function in rats with experimental heart failure. Methods Twenty-four experimental heart failure rat models induced by 1.5% pentobarbital sodium were researched by using hemodynamic method and then were devided into control group(salt solution, 0.9 mg•kg^-1), As group(As, 10 mg•kg^-1) and deslanoside group (deslanoside, 0.04 mg•kg^-1). Every group was controlled with the hemodynamic value 5 minutes after heart failure. Left ventricular systolic pressure (LVSP), left ventricular end diastolic pressure (LVEDP), maximal rising and falling rate of ventricular pressure(±dp/dt^max) were recorded with 4-channel polygraph to observe the the effects of salt solution, Aralosides and deslanoside on cardiac function in rats with experimental heart failure. Results In As group, the LVSP was increased from (10.8±1.0) kPa to (14.5±1.8)kPa (P<0.001)，+dp/dt^max was increased from (163±24)kPa•s^-1 to (295±66)kPa•s^-1 (P<0.001)，-dp/dt^max was decreased from (-140±31) kPa•s^-1 to (-218 ±60) kPa•s^-1 (P<0.01) and LVEDP was decreased from (1.46±0.24) kPa to (1.28±0.17) kPa (P<0.05) after intravenous administration of As. In deslanoside group, the LVSP was increased from (10.5±1.2) kPa to (12.9±1.6) kPa (P<0.01)，+dp/dt^max was increased from (144±26) kPa•s^-1 to (222±53) kPa•s^-1 (P<0.001)，-dp/dt^max was decreased from (-132±23) kPa•s^-1 to (-190±32)kPa•s^-1(P<0.001) ，and LVEDP was decreased from (1.31±0.19) kPa to (1.14±0.18)kPa (P<0.05) after intravenous adminstration of deslanoside. But the hemodynamic value did not change after intravenous administration of salt solution (P>0.05). Conclusion As can induce a positive inotropic action on heart failure myocardium, performing in a similar manner as deslanoside.

Key words: pharmacology, heart failure, hemodynamics, pentobarbital, analoys ＆ derivatives, deslanoside