关键词: 新生血管化, 病理性, 内皮生长因子, 药理学, 抗原, CD34

Abstract: Objective Using skylight tumor model to observe the tumor growth and effects of angiostatin(AS) and endostatin(ES) on tumor. Methods The mice were randomly divided into four groups: blank contrast group, experimental contrast group, low dose experimental group(AS 0.6 ng•kg^-1＋ES：2.5 mg•kg^-1), and high dose experimental group(AS 1.2 ng•kg^-1＋ES 5.0 mg•kg^-1). Mice skylight tumor models were established.After 13 days, the tumor growth was prohibited obviously observed with the naked eye in high dose experimental group and the expressions of CD34 and VEGF were determined with immunohistochemistry to explore mechanism in the course of anti- angiogenesis. Results After the tumor cells had been transplanted into mice, it was difficult for the mice to go in experimental contrast group. But the tumor growth in drug experimental groups were slow and the mice could slow and walk well. The expressions of VEGF and CD34 were higher in experimental contrast group than those in drug experimental groups. Conclusion AS and ES can have important inhibitory effects on angiogenesis.

Key words: neovascularization, pathologic, endothelial growth factors, pharmacology, antigens, CD34