关键词: 抗原, CD95, 细胞凋亡

Abstract: Objective To explore the correlations of the changes of soluble Fas（sFas） levels with pathogenesis of breast diseases. Methods The serum sFas levels in 226 healthy women, 20 patients with recurrent breast cancer, 81 patients with primary breast cancer and 22 patients with benign breast diseases were detected by enzyme-link immunosorbent assay. Results In the healthy group,sFas level increased with age. The mean sFas levels in primary and recurrent cancer patients were 0.815 and 1.510 ng•L^-1，respectively,they were higer than those in healthy controls and benign breast cancer patients (0.580 and 0. 664 ng•L^-1,P<0.05). The sFas levels in patients with primary cancer before surgery and two weeks after surgery were 0.815 and 0.620 ng•L^-1,respectively, the difference was significant (P<0.05). Ths sFas levels in primary cancer patients increased with tumor stages, the difference was significant (P<0.05), but had no correlation with estrogen receptor (ER), progestogen receptor (PR), and local lymphatic metastasis (P>0.05). Conclusion The serum sFas level in patents with breast cancer may be used as a index to judge the development and prognosis of breast cancer.

Key words: antigens, CD95, apoptosis