轮叶党参乙醇提取液预防大鼠脂质代谢紊乱的机制

doi:吉林省科技厅

轮叶党参乙醇提取液预防大鼠脂质代谢紊乱的机制

韩春姬¹，王冬明¹，俞星¹，李莲姬¹，朴永泉²

1. 延边大学医学院卫生学教研室，吉林延吉133000；2.延边大学医学院实验动物科，吉林延吉133000

收稿日期:2004-10-21 修回日期:1900-01-01 出版日期:2005-07-28 发布日期:2005-07-28

Preventive effect of Codonopsis Lanceolata on lipid metabolic disorder in rats and its mechanism

HAN Chun-ji¹, WANG Dong-ming¹, YU Xing¹, LI Lian-ji¹，PIAO Yong-quan²

1. Department of Hygiene, Medical College， Yanbian University, Yanji 133000, China;2. Department of Experimental Animals, MedicalCollege,Yanbian University,Yanji 133000,China

Received:2004-10-21 Revised:1900-01-01 Online:2005-07-28 Published:2005-07-28

摘要/Abstract

摘要： 目的：探讨轮叶党参对大鼠脂质代谢紊乱的预防机制。方法：用高脂饲料喂养大鼠的同时灌胃不同剂量的轮叶党参乙醇提取液（1.5、3.0和6.0 g·kg^-1）8周，测定血清甘油三酯（TG）和相关指标。结果：①轮叶党参中、高剂量组TG和可诱导型一氧化氮合酶活性显著低于高脂对照组（P<0.05），一氧化氮水平和内皮型一氧化氮合酶活性明显高于高脂对照组（P<0.05）。②3种不同剂量轮叶党参组的肝体比值逐渐减小，呈现剂量-效应关系，高剂量组显著低于高脂对照组（P<0.05）。轮叶党参中、高剂量组肝总脂解酶活性、肝脂酶、脂蛋白脂酶均显著高于高脂对照组（P<0.05），且呈剂量-效应关系。结论：增强肝总脂酶的活性、加速脂肪分解和提高抗氧化能力抑制脂质过氧化物是轮叶党参调节血脂的主要机制之一。

关键词: 脂质代谢紊乱, 一氧化氮合酶, 脂解酶, 甘油三酯类

Abstract: Objective To study the preventive effect of Codonopisis Lanceolata (CL) on lipid metabolic disorder in rats and its mechanism. Methods Rats were treated with high-fat diet and the ethanol extract of CL (1.5,3.0, and 6.0 g·kg^-1) simultaneously for 8 weeks. Then the serum TG and other correlated indexes were detected. Results ①The level of TG and the activity of inducible nitric oxide synthase (iNOS) in the middle and high doses of CL groups were decreased significantly compared with model group (P<0.05), and nitrogen monoxidum（NO）level and endothelial nitric oxide synthase (eNOS) activity were increased (P<0.05). ②The ratio of liver weight to body weight (HW/BW) was lowered gradually in different dose groups and showed dose-effect correlation. It was lower in high dos e group than that in model group significantly (P<0.05). The activities of lipases, including total lipase activity in the liver (LA), lipoprotein lipase (LPL) and hepatic lipase (HL) were increased significantly in the middle and high doses of CL groups compared with model group (P<0.05), and showed dose-effect correlation. Conclusion Increasing LA to accelerate the lipid metabolism and increasing the activity of anti-oxidant to inhibit the produce of lipid peroxidation is one of the main mechanism of CL regulating blood lipid. Key words：Codonopsis Lanceolata; lipid metabolic disorder; ni tric-oxide synthase; lipolyic enzyme；triglycerides

Key words: lipid metabolic disorder, ni tric-oxide synthase, lipolyic enzyme, triglycerides

中图分类号:

R-332

韩春姬，王冬明，俞星，李莲姬，朴永泉. 轮叶党参乙醇提取液预防大鼠脂质代谢紊乱的机制[J]. J4, 2005, 31(4): 564-566.

HAN Chun-ji, WANG Dong-ming, YU Xing, LI Lian-ji，PIAO Yong-quan. Preventive effect of Codonopsis Lanceolata on lipid metabolic disorder in rats and its mechanism[J]. J4, 2005, 31(4): 564-566.

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