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哮喘儿童血清白细胞介素4、转化生长因子β1及IgE水平的变化及临床意义

李善玉1,2， 赵凯姝1，李 波3，鲁继荣1， 魏景艳2*   

  1. 1. 吉林大学第一医院儿科，吉林 长春 130021；2. 吉林大学药学院生物工程教研室，吉林 长春 130021；3. 吉林大学公共卫生学院流行病学教研室，吉林 长春 130021
  • 收稿日期:2005-02-03 修回日期:1900-01-01 出版日期:2005-07-28 发布日期:2005-07-28
  • 通讯作者: 魏景艳

Changes of serum IL-4,TGFβ1 and IgE levels in asthmatic children and their clinical significances

LI Shan-yu1,2，ZHAO Kai-shu1，LI Bo3，LU Ji-rong1，WEI Jing-yan2*   

  1. 1. Department of Pediatrics,First Hospital, Jilin University,Changchun 130021, China; 2. Department of Bioengineering, School of Pharmacy,Jilin University,Changchun 130021, China;3. Department of Epidemiology, School of Public Health, Jilin University，Changchun 130021, China
  • Received:2005-02-03 Revised:1900-01-01 Online:2005-07-28 Published:2005-07-28
  • Contact: WEI Jing-yan

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摘要： 目的：探讨哮喘儿童血清白细胞介素4（IL-4）、转化生长因子β1（TGFβ1）及IgE水平变化及临床意义。 方法：对98例哮喘患儿应用双抗体夹心ELISA法，检测血清IL-4、TGFβ1、IgE水平，其中发作期42例、缓解期56例；设正常对照52例。 结果：在哮喘组，血清IL-4、IgE水平明显高于对照组［（12.09±6.00） ng·L-1,(58.16±15.47) ng·L-1］（P<0.05），TGFβ1水平显著低于对照组［（181.59±96.05）ng·L-1］（P<0.05）；在发作期血清IL-4、IgE水平［（105.86±34.33）ng·L-1,(270.21±74.84) ng·L-1］均高于缓解期［（61.58±11.04）ng·L-1,(152.80±45.15) ng·L-1］ （P<0.05），在发作期血清TGFβ1水平［（41.97±12.77） ng·L-1］均低于缓解期［(63.40±23.40) ng·L-1］（P<0.05）。IL-4与IgE呈正相关（r=0.581，P<0.001），TGFβ1分别与IL-4、IgE呈负相关（r1=-0.614，P<0.001；r2=-0.609，P<0.001）。 结论：IL-4可促进哮喘患儿IgE分泌，并抑制嗜酸性粒细胞产生TGFβ1，这一机理在哮喘 发病中起重要作用。

关键词: 血液, 白细胞介素4, 血液, 转化生长因子β1<, sub>, 血液, 免疫球蛋白E, 血液

Abstract: LI Shan-yu1,2，ZHAO Kai-shu1，LI Bo3，LU Ji Objective To explore the changes of serum IL-4, TGFβ1 and IgE levels in asthmatic children and their clinical significances. Methods The serum IL-4,TGFβ1 and IgE levels of ninety-eight asthmatic children, including forty-two in acute attack group and fifty-six in remission group, and fifty-two healthy children in normal control group were detected by Sandwich ELISA. Results The serum IL-4 and IgE levels in asthmatic groups increased （P<0.05），whereas TGFβ1 level decreased （P<0.04），Both IL-4 and IgE levels (ng·L-1) in acute attack group (105.86±34.33,270.21±74.84) were higher than those in remission group (61.58±11.04，52.80 ±45.15)（P<0.05）. But the TGFβ1 level (ng·L-1) in acute group (41.97±12.77) was lower than that in remission group　(63.40±23.40)（P<0.05）. There was positive correlation between the levels of IL-4 and IgE (r=0.581,P<0.001). However, there were negative correlations between the levels of TGFβ1 and IL-4 or IgE (r1 =-0.614, P<0.001；r2=-0.609，P<0.001). Conclusion IL-4 can accelerate secretion of IgE in asthmatic children and restrain eosinophilic granulocyte from secreting TGFβ 1, thereby play an important role in asthmatic pathogenesis.

Key words: blood, interleukin-4, blood, transforming growth factor beta, blood, immunoglobulin E, blood

中图分类号: 

  • R725.6
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