关键词: 动脉硬化, 血管细胞黏附分子-1, C反应蛋白

Abstract: Objective To measure the levels of serum vascular cell adhesion molecule-1(VACM-1),intercellular adhesion molecule-1 (ICAM-1) and C-reactive protein（CRP） in patients with acute coronary syndrome (ACS), and to explore their significances in diagnosis and treatment of coronary heart disease. Methods The levels of serum VACM-1,ICAM-1 and CRP were measured in 50 patients with ACS undergoing coronary angiography as well as 50 controls. Results The levels of serum VACM-1,ICAM-1 and CRP in patients with ACS were higher than those in controls (701±54.6 μg·L^-1vs 556±42.2 μg·L^-1,389±23.7 μg·L^-1 vs 271±34.6 μg·L^-1,7.05±3.13 mg·L^-1 vs 4.22±1.41 mg·L^-1)(P<0.01)；the levels of VACM-1 and ICAM-1 between acute myocardial infraction（AMI） and unstable angina（UA） patients were not difference (699.12±62.77 μg·L^-1 vs 706.57±53.65 μg·L^-1,390.39±42.34 μg·L^-1 vs 372.63±32.59 μg·L^-1)(P>0.05)；CRP content in AMI patients was higher than that in UA patients （8.06±2.78 mg·L^-1 vs 6.33±2.01 mg·L^-1）(P<0.05). Conclusion The stenosis and block caused by atherosclerosis plaque accompany the increase of VACM-1,ICAM-1 and CRP, and there is a relation with condition of the disease. The excess expression of adhesion molecules may be an important factor of atherosclerosis. Adhesion molecule might become a testindex to monitor the occurrence and development of atherosclerosis.

Key words: arterosclerosis, vascular cell adhesion molecule-1, C-reactive protein