关键词: 肿瘤抑制, 视网膜母细胞瘤蛋白质, 乳腺肿瘤

Abstract: Objective To study the expression of retinoblastoma (Rb) protein in patients with breast cancer and its significance. Methods The expressions of Rb protein were detected in 52 patients with breast cancer, 20 patients with breast fibroadenoma or breast cystic hyperplasia (control group) by S-P immunohistochemical method. Results The negative rate of Rb expression in breast cancer (76.91%) was higher than that in control group (15.00%)(P<0.01).There was no relationship between the negative rate of Rb expression and the clinical pathological parameters in the patients with breast cancer (P>0.05). Of all 46 follow-up patients with breast cancer, the peritoneal recurrence and metastatic rate was 10.53% in 38 cases of the negative expression of Rb protein, and while the rate was 0 in 8 cases of the positive expression of Rb protein, there was significant difference (P<0.01). Conclusion The negative expression of Rb protein may be related to the initiation of breast cancer; as an tumor suppressor genes product,Rb protein may be considered as a new clinical indicator for monitor of breast cancer and provide information for adjuvant therapy.

Key words: tumor suppressor, retinoblastoma protein, breast neoplasms