吉林省科技厅资助课题（990569）

doi:吉林省科技厅资助课题（990569）

吉林省科技厅资助课题（990569）

刘静珠^1*，林丽^1,2，胡静¹，张士平³，张爽⁴，樊静^1,5

1. 吉林大学第二医院妇产科，吉林长春130041；2. 山东省聊城市人民医院妇产科，山东聊城 252000；3. 吉林大学中日联谊医院内科，吉林长春 130033；4. 吉林大学社会科学院，吉林长春132012；5. 浙江省宁波市妇女

收稿日期:2005-05-30 修回日期:1900-01-01 出版日期:2006-05-28 发布日期:2006-05-28
通讯作者: 刘静珠

Relationship between recurrent spontaneous abortion and anti-β₂-glycoprotein Ⅰ antibody

LIU Jing-zhu^1*，LIN Li^1,2，HU Jing¹， ZHANG Shi-ping¹，ZHANG Shuang¹，FAN Jing^1,5

1.　Department of Obstetrics and Gynecology, Second Hospital, Jilin University, Changchun 130041,China;2. Department of Obstetrics and Gynecology, People′s Hospital of Liaocheng City,Liaocheng 252000,China;3. Department of InternalMedicine， China-Japan Union Hospital, Jilin University, Changchun 130033,China;4. School of Social Science, Jilin University Changchun, 130021,China；5. Ningbo Womenand Children′s Hospital,Ningbo 315012,China

Received:2005-05-30 Revised:1900-01-01 Online:2006-05-28 Published:2006-05-28
Contact: LIU Jing-zhu

摘要/Abstract

摘要： 目的：探讨抗β₂-糖蛋白Ⅰ抗体（anti-β₂-GP Ⅰ antibody）与反复自然流产(RSA)的关系。方法：采用酶联免疫吸附法检测81例RSA患者和39例正常妇女血清中anti-β₂-GP Ⅰ的水平。结果：RSA组anti-β₂-GPⅠ及其IgG型抗体阳性率分别为42.0%和40.8%，显著高于对照组（7.7%）（P<0.01，P<0.05）；IgM型抗体阳性率与对照组比较差异无显著性（P>0.05）；早期与中晚期RSA两组间及RSA 2次与RSA≥3次两组间阳性率比较差异均无显著性（P>0.05）。结论：anti-β₂-GP Ⅰ与RSA有关，可作为RSA免疫因素的辅助诊断指标。

关键词: 习惯性, 抗β_2<, sub>-糖蛋白Ⅰ抗体, 酶联免疫吸附测定

Abstract: Objective To explore the relationship between recurrent spontaneous abortion (RSA) and anti-β₂-glycoprotein Ⅰ(anti-β₂-GP Ⅰ) antibody. Methods The levels of anti-β₂-GP Ⅰ antibody in serum from 81 RSA patients and 39 normal women were detected by ELISA. Results The positive rate of anti-β₂-GP Ⅰ in RSA patients (42.0%) was obviously higher than that in normal women (7.7%) (P<0.01); there was obvious difference of the positive rate of anti-β₂-GP Ⅰ IgG in statistics between RSA patients (40.8%) and normal women(7 .7%)（P<0.05）, and there was no difference of the positive rate of anti-β₂-GP Ⅰ IgM in statistics between RSA patients and normal women (P>0.05). There was no difference of the positive rate of anti-β₂-GP Ⅰ in statistics between early and late, as well as between 2 times and more than 2 times abortions of RSA (P>0.05). Conclusion The anti-β₂-GP Ⅰ antibody is related to RSA, and it may be regarded as a immunological assistant diagnostic index for RSA.

Key words: habitual, anti-β_2<, sub>-glycoprotein Ⅰ antibody, enzyme linked immunosorberent assay

中图分类号:

R714.21

刘静珠，林丽，胡静，张士平，张爽，樊静. 吉林省科技厅资助课题（990569）[J]. J4, 2006, 32(3): 486-488.

LIU Jing-zhu，LIN Li，HU Jing， ZHANG Shi-ping，ZHANG Shuang，FAN Jing. Relationship between recurrent spontaneous abortion and anti-β₂-glycoprotein Ⅰ antibody[J]. J4, 2006, 32(3): 486-488.

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