关键词: 心血管, 子痫, 滋养层, 免疫学, 抗体

Abstract: Objective To investigate the relationship between anti-trophoblast membrane antigens(TA) antibodies and hypertensive disorders complicating pregnancy(HDCP). Methods Enzyme linked immunosorbent assay(ELISA) was used to detect anti-TA IgG and IgM in both maternal and umbilical serum samples of 40 normal pregnant women and 92 HDCP women(23 gestational hypertension or mild preeclampsia, 41 severe preeclampsia and 28 eclampsia). Results The positive rates of anti-TA IgG and IgM in maternal serum samples with HDCP , eclampsia or severe preeclam psia were significantly higher than that in normal pregnant women ，the positiv e rate of anti-TA IgM increased significantly with the aggravation of HDCP(P<0.05). The positive rates of anti-TA IgG in umbilical serum samples with HDCP, eclampsia or severe preeclampsia were significantly higher than that in normal pregnant women(P<0.05). The positive rates of anti-TA IgM in patients with HDCP or eclampsia were significantly higher than that in normal pregnant women(P<0.05).The positive rate of anti-TA IgM in HDCP patients with fetal growth restriction (FGR) was significantly higher than that in those without FGR(P<0.05). Conclusion The anti-TA IgG and IgM in maternal and umbilical serum increase in HDCP patients, and the increasing of anti-TA IgM in maternal serum is associated with the aggravation of HDCP.

Key words: cardiovascular, eclampsia, trophoblasts, immunology, antibodies