关键词: 上皮细胞, 内皮细胞, 微血管, 水通道蛋白

Abstract: Abstract:Objective To study the distribution and expressions of aquaporin(AQP) 1,2,3 in human cystitis glandularis tissue.Methods The expressions and distribution of AQP1,AQP2,AQP3 in 30 cases of cystitis glandularis tissue and 30 cases of normal bladder tissue were detected by immunohistochemistry technique,and the gray scale values of the dyeing consequence were examined by computer.Results In cystitis glandularis tissue AQP1 mainly expressed in the endothelial cells of micrangium,the immunohistochemical positive exponent was 35.947；AQP2 expressed in the cell membrane and periplasm of the mucosa epithelial cells，the immunohistochemical positive exponent was 34.644；and AQP3 did not express.In normal bladder tissue, AQP1 mainly expressed in the endothelial cells of capillary and arteriolar under the mucous membrane of urinary bladder,AQP2 and AQP3 expressed in the celluar membrane and periplasm of the mucous membrane of urinary bladder.The immunohistochemical positive exponent of AQP1,AQP2,AQP3 in the normal bladder tissue were 57.038，61.425 and 60.468，respectively,there were significant differences compared with AQPs in the cystitis glandularis tissue P<0.01）. Conclusion The expressions of AQPs are obviously reduced in cystitis glandularis tissue,and the inflammation affects the expression of AQPs.

Key words: epithelium, endotheliocyte, capillary, aquaporin