关键词: 血液, 肾小球肾炎, 血液 , 纤维化

Abstract: Abstract:Objective To study the change of matrix metalloproteinase-2 (MMP-2) in the development of renal fibrosis and evaluate the diagnostic value of blood MMP-2 level in renal fibrosis.Methods Thirty three patients with chronic glomerulonephritis were divided into proliferation group(n=18) and fibrosis group(n=15) according to renal fibrosis degree in renal pathology.Another 8 healthy subjects were used as control group.The levels of pro-MMP-2 and MMP-2 in serum were measured with the method of SDS-PAGE enzymography.Then the levels of pro-MMP-2 and MMP-2 in serum were compared between various groups.Results The serum MMP-2 level in proliferation group was much higher than that in control group(P<0.01) and it was lower in fibrosis group than that in control group(P<0.05).Compared with proliferation group,the content of urine protein in fibrosis group decreased obviously(P<0.01),serum fibrinogen level increased markedly(P<0.05),FN increased (P<0.01);there were no obvious differences of plasma lipid and creatinine level(P>0.05).Conclusion There is a significant difference of serum MMP-2 between suffering group and normal control group.Therefore the detection of serum MMP-2 level can be conducive to understand the development of disease and estimate prognosis.

Key words: blood , glomerulonephritis, blood , fibrosis