关键词: 万古霉素, 感染, 体外实验

Abstract: Abstract:Objective To study the effects of vancomycin-impregnated polymethylmethacrylate (VCM-PMMA) on mechanics alteration and delayed release in order to guide clinical application.Methods The specimens of bone cement (each of 40 g) were divided into 7 groups depending on mixed different contents with vancomycin，containing 0，0.5,1.0,1.5,2.0,2.5 and 3.0 g vancomycin.The compressive strength,bending strength and bending elastic moduls were measured respectively.The elution examination of vancomycin from bone cement was performed by chromatography.Results There were no differences of compressive strength before elution of bone cement that were included from 0 to 3.0 g vancomycin.When the vancomycin in the content of the bone cement attained 3.0 g,the compressive strength after elution and bending elastic were lower than those in control group（P<0.05）.Bending modulus of every group had no difference. In the release test,the elution rate in every group increased progressively with the content of vancomycin in polymethylmethacrylate at first week.When the vancomycin in the content of bone cement attained from 1.5 to 2.0 g after a week,the quantity of the released vancomycin was higher than the others（P<0.05）,and it was gradually in stability.Conclusion Vancomycin can be released from the bone cement utility.1.5-2.0 g vancomycin are optimal doses to be impregnated in 40 g bone cement and they can improve the mechanical property of the bone cement.

Key words: vancomycin, infection, in vitro