关键词: 抗炎作用, 镇痛作用, 药效学

Abstract: Abstract:Objective To investigate anti-inflammatory effects and analgesic effects of Qianlie Shutong Tablets(QLS) and provide medical basis for its clinical use.Methods A total of 40 rats or mice were randomly assigned into control group(n=8),drug control (Aspirin,n=8) group,low -dose QLS (mice: 25 mg•kg^-1•d^-1,n=8;rats: 17.5 mg•kg^-1•d^-1,n=8) group,mid-dose QLS (mice: 50 mg•kg^-1•d^-1,n=8;rats: 35.0 mg•kg^-1•d^-1,n=8) group and high -dose QLS (mice: 100 mg•kg^-1•d^-1;rats: 70.0 mg•kg^-1•d^-1) group.Anti-inflammatory effects were tested by xylene-induced ear edema in mice,ovoalbumin-induced feet edema and cotton pellet-induced granuloma in rats.Analgesic effects were tested by hot-plate method and 0.6 % acetic acid solution injected into the mice abdominal cavity to produce pain in order to cause the body bend.Different doses of QLS were given and their actions were observed.Results QLS had obvious anti-inflammatory effectts on the xylene-induced ear edema.Compared with control group,ear edema was significantly decreased by QLS with the doses of 50 and 100 mg•kg^-1•d^-1 (P<0.05 or P<0.01),the ear edema inhibitory rates were 53.97 % and 60.09 % in mice,respectively.Ovoalbumin-induced rat feet edema was significantly decreased by QLS with the doses of 35 and 70.0 mg•kg^-1•d^-1 (P<0.05).Cotton pellet-induced rat granuloma was significantly decreased by QLS with the doses of 35.0 and 70.0 mg•kg^-1•d^-1 (P<0.05 or P<0.01 ) and the granuloma inhibitory rates were 32.40 % and 35.65 %,respectively.Pain thresholds 90,90 and 30min after administration were markedly elevated (P<0.05 or P<0.01) and the licking-paw latencies in hot plate method were extended by QLS with the doses of 25,50 and 100 mg•kg^-1•d^-1 (P<0.05),the inhibitory rates of pain threshold were 36.17%,44.13%,and 46.64%,respectively.Conclusion QLS has significant anti-inflammatory and analgesic effects.

Key words: anti-inflammatory effects, analgesic effects, pharmacodynamics