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食盐加碘前后甲状腺恶性肿瘤检出率及组织学类型分析

崔俊生1,倪劲松2,孔庆扬1,王 静*   

  1. (1.吉林大学中日联谊医院病理科,吉林 长春 130033;2.吉林大学基础医学院 病理生物学教育部重点实验室,吉林 长春 130021)
  • 收稿日期:2007-08-25 修回日期:1900-01-01 出版日期:2008-11-28 发布日期:2008-11-28
  • 通讯作者: 倪劲松

Analysis of detection rate of thyroid malignant tumor before and after universal salt iodization and histological types

CUI Jun-sheng1,NI Jin-song2,KONG Qing-yang1,WANG Jing*   

  1. (1.Department of Pathophysiology,China-Japan Union Hospital,Jilin University,Changchun 130012,China; 2.Key Laboratory of Pathobiology,Ministry of Education,School of Basic Medical Sciences, Jilin University,Changchun 130021,China )
  • Received:2007-08-25 Revised:1900-01-01 Online:2008-11-28 Published:2008-11-28
  • Contact: NI Jin-song

摘要: 目的: 探讨食盐加碘前后甲状腺恶性肿瘤的检出率及组织学类型构成的变化。方法: 回顾性查阅1961—2000年外检病理登记资料, 对其中1011例甲状腺恶性肿瘤依据WHO新分类标准进行重新分类,统计分析食盐加碘前后甲状腺恶性肿瘤检出率、组织学类型的构成比及甲状腺主要恶性肿瘤的年龄和性别分布变化。 结果:食盐加碘后甲状腺恶性肿瘤检出率为0.69%,明显高于加碘前的0.46%(P<0.01);食盐加碘前后甲状腺恶性肿瘤构成比出现明显变化,甲状腺乳头状癌在食盐加碘后构成比(70.17%) 高于加碘前(55.84%),而甲状腺滤泡癌在食盐加碘后的构成比(11.08%) 低于加碘前 (24.58%);食盐加碘前甲状腺恶性肿瘤发病高峰年龄为(40.95±14.71)岁,加碘后发病高峰年龄为(43.06±13.09)岁,发病年龄有增加趋势(P<0.05);食盐加碘前甲状腺乳头状癌、滤泡癌及未分化癌的高发年龄均≤40岁,加碘后3种癌的高发年龄均>40岁;食盐加碘前后女性甲状腺恶性肿瘤检出率均高于男性(P<0.05)。结论: 食盐加碘后甲状腺恶性肿瘤检出率增高,甲状腺癌的组织类型发生变化:乳头状癌显著增加,滤泡状癌减少;甲状腺乳头状癌、滤泡癌及未分化癌的发病年龄有增加趋势。

关键词: 组织学类型, 食盐加碘

Abstract: To investigate and evaluate the detection and the variety of histology type constituent of the thyroid malignant tumor before and after universal salt iodization.Methods 1011 clinical pathological data of thyroid malignant tumor confirmed pathologically from 1961 to 2000 was retrospectively analyzed.The detection rate of thyroid malignant tumor,the constituent ratios of each histology type and the changes of age and sex distribution in main types of thyroid malignant tumor were determined.Results The total detection rate of thyroid malignant tumor after universal salt iodization (USI) (0.69%) were obviously increased compared with before universal salt iodization(0.46%,P<0.01).The constituent ratios of thyroid malignant tumor showed differences before and after universal salt iodization (P<0.01).The proportion of papillary carcinoma (70.17%) increased obviously after USI compared with before USI (55.84%).The proportion of follicular carcinoma (11.08%) decreased accordingly after USI compared with before USI (24.58%).The average age of thyroid malignant tumor sufferers (43.06±13.09 years old) after USI increased(P<0.05) compared with before USI (40.95±14.71 years old).The peak ages of papillary carcinoma(PC),follicular carcinoma (FC) and undifferentiated carcinoma(UC) were increased after USI(>40 years old) than before USI(≤40 years old).The incidence rates of thyroid malignant tumor in female patients were higher than male patients before and after USI.Conclusion The proportion and average age of thyroid malignant tumor increases after USI.The histological types of thyroid carcinoma have changes after USI: the proportion of PC increases obviously,the proportion of FC decreases accordingly.The average age of thyroid malignant tumor sufferers tends to increase and the peak ages of PC,FC and UC raise after USI.

Key words: histological type, universal salt iodization

中图分类号: 

  • R736.1