泪囊黏膜中免疫分子的表达及其临床意义

J4 ›› 2009, Vol. 35 ›› Issue (4): 710-713.

泪囊黏膜中免疫分子的表达及其临床意义

张涛¹, 王继群¹, 王丽华¹, 王全军², 涂智峰¹

1.暨南大学附属第一医院耳鼻咽喉科|广东广州 510630；2. 华南农业大学医院五官科|广东广州510642

收稿日期:2008-12-11 出版日期:2009-07-28 发布日期:2009-08-24
通讯作者: 张涛 E-mail:tzhangt@jnu.edu.cn
作者简介:张涛(1965-)|男|吉林省长春市人|副教授|副主任医师|医学博士|主要从事鼻科学、鼻眼相关外科学研究。
基金资助:
广东省科技厅自然科学基金资助课题(06300585)

Expressions of immunity molecules in lacrimal sac mucosaand its clinic significances

ZHANG Tao¹, WANG Ji-Qun¹, WANG Li-Hua¹, WANG Quan-Jun², TU Zhi-Feng¹

1.Department of Otorhinolaryngology|First Affiliated Hospital|Jinan University|Guangzhou 510630,China;2. Department of ENT,South China Agricultural University Community Hospital,Guangzhou 510642,China

Received:2008-12-11 Online:2009-07-28 Published:2009-08-24

摘要/Abstract

摘要：

目的：检测泪囊黏膜中是否存在免疫分子，探讨泪囊黏膜中黏膜相关淋巴组织的免疫功能。方法：利用免疫组织化学SP法对8例正常人泪囊黏膜中的IgA、IgG、SC和Lysozyme分别进行检测，并同时检测以上4种分子在正常下鼻甲黏膜中的表达情况，分别比较4种免疫分子在两种黏膜中的表达情况。 结果：IgA、IgG、SC和Lysozyme在泪囊和下鼻甲黏膜中均有不同程度的阳性表达，以上4种免疫分子除IgA在下鼻甲黏膜的表达强度高于泪囊黏膜外（P<0.05），其他3种免疫分子在两种黏膜中的表达强度比较差异无显著性（P>0.05
）。而且4种免疫分子在两种黏膜的表达率比较差异无显著性（P>0.05）。结论：泪囊黏膜具有IgA、IgG、SC和Lysozyme等免疫分子，且有完善的黏膜免疫功能；在泪囊疾病的治疗中应注意保护泪囊黏膜。

关键词: 泪囊；黏膜；免疫功能

Abstract:

Abstract:Objective To observe whether there are some immunity molecules in the lacrimal sac mucosa,and to testify the immune ability of lacrimal sac mucosa associated lymphoid tissue (MALT). Methods The primary antibodies (IgA,IgG,SC, and
lysozyme) in 8 normal human lacrimal sac mucosa were detected with SP method, at the same time the IgA,IgG,SC,and lysozyme in the inferior turbinate mucosa were al
so detected. Results The positive expressions of IgA,IgG,SC and lysozyme in the inferior turbinate and lacrimal sac mucosa were found. The expressions of IgA in the inferior turbinate mucosa was stronger than that in lacrimal sac mucosa (P<0.05). The expressions of IgG,SC and lysozyme were similar in both tissues (P>0.05). The positive cell expression rates of all immunity molecules in both tissues were similar（P>0.05）. Conclusion The lacrimal sac mucosa contains IgA,IgG,SC and lysozyme. It suggests that lacrimal sac mucosa posses the immune function;the mucosa should be protected during the treatment of lacrimal sac diseases.

Key words: lacrimal sac; , mucosa; , immunity molecule

中图分类号:

R777.22

张涛, 王继群, 王丽华, 王全军, 涂智峰. 泪囊黏膜中免疫分子的表达及其临床意义[J]. J4, 2009, 35(4): 710-713.

ZHANG Tao, WANG Ji-Qun, WANG Li-Hua, WANG Quan-Jun, TU Zhi-Feng. Expressions of immunity molecules in lacrimal sac mucosaand its clinic significances[J]. J4, 2009, 35(4): 710-713.