J4 ›› 2009, Vol. 35 ›› Issue (6): 1032-1035.

• 基础研究 • 上一篇    下一篇

长白忍冬花蕾化学成分的分离与结构鉴定

 崔晶, 王广树   

  1. (吉林大学药学院生药教研室|吉林 长春 130021)
  • 收稿日期:2009-03-03 出版日期:2009-11-28 发布日期:2009-11-28
  • 通讯作者: 王广树 E-mail:wgs@jlu.edu.cn
  • 作者简介:崔 晶(1978-)|女|吉林省农安县人|在读医学硕士|主要从事中草药有效成分的研究。
  • 基金资助:

    国家科技部支撑计划项目资助课题(2006BAI06A18-17)

Isolation and structure identification of chemical constituents from buds of Lonicera ruprechtiana Regel

 CUI Jing, WANG Guang-Shu   

  1. (Department of Pharmacognosy,School of Pharmacy,Jilin University,Changchun 130021,China)
  • Received:2009-03-03 Online:2009-11-28 Published:2009-11-28

摘要:

目的:分析长白忍冬(Lonicera ruprechtiana Regel.)花蕾中的化学成分,为进一步开发利用其药用价值提供实验数据。方法:以长白忍冬的干燥花蕾为原材料,用70%的乙醇冷浸提取,经大孔树脂柱色谱纯化,用硅胶、ODS柱色谱分离其化学成分,利用紫外光谱测定仪、红外光谱仪、核磁共振仪测定其化学成分的光谱学数据。结果:根据在薄层色谱中呈现单一斑点结果,从长白忍冬花蕾中分离得到5个化合物,经理化常数测定及光谱学数据分析鉴定其化学结构。其结构分别为:胡萝卜苷(Ⅰ),7S-O-甲基莫罗忍冬苷(Ⅱ),新橙皮糖苷(Ⅲ),苯甲基-O-β-D-吡喃木糖-(1→6)-β-D-吡喃葡萄糖苷(Ⅳ),6′-O-β-D- 呋喃芹糖基獐牙菜苷(Ⅴ)。结论:该5个化合物均系首次从长白忍冬花蕾中分离得到。  

关键词: 忍冬/化学;环烯醚萜苷;黄酮苷

Abstract:

Abstract:Objective To explore the medicinal values of the buds of Lonicera ruprechtiana Regel.by analyzing its chemical constituents. Methods The buds of Lonicera ruprechtiana Regel.were extracted with 70% ethanol,the extractives were purified with  macroporous resin and isolated with silica gel and ODS column chromatography.NMR,UV,IR Spectrometers were used to obtain spectroscopic data.
Results According to the single spot in TLC,five compounds were isolated from the buds of Lonicera ruprechtiana Regel.,and their structures were identifited through physico-chemical constants and spectroscopic analysis.Five compounds were isolated from the buds of Lonicera ruprechtiana Regel.,and they are daucosterol (Ⅰ);7S-O-methylmorroniside(Ⅱ);neohesperidin(Ⅲ);benzyl-O-β-D-xylopyranosyl-(1→6)-β-D-glucopyranoside (Ⅳ);6′-O-β-D-apiofuranosyl sweroside (Ⅴ).Conclusion  All these compounds are isolated from the buds of Lonicera ruprechtiana Regel.for the first time.

Key words: Lonicera japonica/chemistry;iridoid glycoside;flavonoid glycoside

中图分类号: 

  • R284