牙本质基质蛋白1在涎腺肿瘤组织中的表达

J4 ›› 2010, Vol. 36 ›› Issue (2): 368-371.

牙本质基质蛋白1在涎腺肿瘤组织中的表达

赵轩一¹|姜秋²|张泽兵¹|王渝¹|孙宏晨¹|白宇¹

1.吉林大学口腔医院病理科|吉林长春 130021;2.吉林大学口腔医院儿童牙病科|吉林长春 130021

收稿日期:2009-09-29 出版日期:2010-03-28 发布日期:2010-03-28
通讯作者: 张泽兵（Tel:0431-88796010,E-mail:zhangzeb@tom.com) E-mail:zhangzeb@tom.com
作者简介:赵轩一（1981-）|男|吉林省通化市人|助教|医学硕士|主要从事口腔病理肿瘤学研究。
基金资助:
吉林省科技厅科研基金资助课题（200705347）

Expression of dentin matrix protein 1 in salivavy gland tumor tissue

ZHAO Han-Yi¹, JIANG Qiu², ZHANG Ze-Bing¹, WANG Yu¹, SUN Hong-Chen¹, BAI Yu¹

1.Department of Pathology,Stomatology Hospital,Jilin University,Changchun 130021,China;2.Department of Pedodontics,Stomatology Hospital,Jilin University,Changchun 130021,China

Received:2009-09-29 Online:2010-03-28 Published:2010-03-28

摘要/Abstract

摘要：

目的：检测牙本质基质蛋白1（C-DMP1）在涎腺多形性腺瘤、黏液表皮样癌组织中的表达，探讨C-DMP1在涎腺肿瘤发生中的作用。方法：采用免疫组织化学方法，在显微镜下观察C-DMP1在30例涎腺良性肿瘤和30例恶性肿瘤组织中的分布及表达情况。结果：多形性腺瘤组织中，导管外层肌上皮细胞和黏液软骨样细胞大部分胞核显示为黄色，C-DMP1呈弱阳性表达，个别细胞胞核显示为棕褐色，呈强阳性表达，强阳性表达率为6.6%;C-DMP1在黏液表皮样癌组织中表皮样细胞胞核显示为棕褐色，呈强阳性表达，部分中间细胞胞核显示为黄色，呈弱阳性表达，而黏液细胞胞核呈阴性表达，强阳性表达率为73.3%。C-DMP1在涎腺良、恶性肿瘤组织中强阳性表达率比较差异具有显著性（P<0.05）。结论：C-DMP1在涎腺良、恶性肿瘤组织中有着不同表达变化及其分布情况，提示C-DMP1可能参与涎腺肿瘤的发生。

关键词: 牙本质基质蛋白1；多形性腺瘤；黏液表皮样肿瘤；免疫组织化学

Abstract:

Abstract:Objective Through detecting the expression of dentin matrix protein 1 (C-DMP1) in pleomorphic adenoma and mucoepidermoid carcinoma tissues to investigate the role of expression of C-DMP1 in the oncogenesis of salivary gland tumor.Methods The immunohistochemical method was used to observe the expression of C-DMP1 in 30 cases of benign salivary gland tumor and 30 cases of malignant salivary gland tumors.Results In mucoepidermoid carcinomas,the expression of C-DMP1 in the epidermoid cells was strongly positive,in the nuclei part of the intermediate cells was weakly positive,while the mucous cells were negative,the strongly positive expression rate was 73.3%;In pleomorphic adenoma,part of the nuclei of ductal cells,outer myoepithelial cells and cartilage-like cells were weakly positive,with only a few strongly positive,the strongly positive expression rate was 6.6%.There was significant difference in the stongly positive expression rate of C-DMP1 between benign and malignant tumors in salivary gland (P<0.05).Conclusion The expression of C-DMP1 in the benign and malignant salivary gland tumor tissue has different changes in its distribution,it suggests that C-DMP1 may participate in the oncogenesis of salivary gland tumor.

Key words: dentin matrix protein 1;pleomorphic adenoma;mucoepidermoid tumor;immunohistochemistry

中图分类号:

R739.8

赵轩一, 姜秋, 张泽兵, 王渝, 孙宏晨, 白宇. 牙本质基质蛋白1在涎腺肿瘤组织中的表达[J]. J4, 2010, 36(2): 368-371.

ZHAO Han-Yi, JIANG Qiu, ZHANG Ze-Bing, WANG Yu, SUN Hong-Chen, BAI Yu. Expression of dentin matrix protein 1 in salivavy gland tumor tissue[J]. J4, 2010, 36(2): 368-371.