132例早产儿消化道出血及凝血功能变化分析

J4 ›› 2010, Vol. 36 ›› Issue (4): 772-774.

132例早产儿消化道出血及凝血功能变化分析

吴伟晴¹|吴本清¹|李志光¹|吴伟²

1.广东省深圳市人民医院新生儿科|广东深圳 518020；2.广东省深圳市龙岗区中心医院|广东深圳 518116

收稿日期:2010-04-19 出版日期:2010-07-28 发布日期:2010-07-28
通讯作者: 吴本清（Tel：0755-25533000，E-mail：wubenqing783@126.com） E-mail:wubenqing783@126.com
作者简介:吴伟晴(1971-)|女|广东省开平市人|副主任医师|主要从事新生儿疾病的诊治研究。
基金资助:
广东省深圳市重点学科基金项目资助课题（20091998A03）

Analysis of coagulation function in 132 premature infants with gastrointestinal hemorrhage

WU Wei-Qing¹, WU Ben-Qing¹, LI Zhi-Guang¹, WU Wei²

1.Department of Newborn,Shenzhen Peaple’s |Hospital of Guangdong Province,Shenzhen 518020,China|2.Shenzhen Longgang Central Hospital,Shenzhen 518116,China

Received:2010-04-19 Online:2010-07-28 Published:2010-07-28

摘要/Abstract

摘要：

目的:探讨早产儿消化道出血与凝血功能变化的关系。方法：选择本院新生儿科收治的132例消化道出血早产儿（观察组）和156例无新生儿出血症、应激性胃黏膜病变、重症感染等并发症的早产儿（对照组），检测凝血酶原时间（PT）、激活的部分凝血活酶时间（APTT）、凝血酶时间（TT）、纤维蛋白原(Fib)及D-二聚体（D-D），比较两组早产儿凝血功能，观察消化道出血早产儿凝血功能的变化。结果：观察组凝血功能与对照组比较，血浆PT、APTT、TT明显延长（P<0.01），Fib明显降低（P<0.01），D-D明显升高（P<0.01）。结论：消化道出血早产儿凝血功能存在明显障碍，早产儿的凝血功能变化与消化道出血密切相关，早产儿凝血功能的异常改变参与了早产儿消化道出血的发病机制。

关键词: 早产儿；消化道出血；凝血酶原时间；激活的部分凝血活酶时间；凝血酶时间；纤维蛋白原；D-二聚体

Abstract:

Abstract:Objective To discuss the relationship between coagulation function and gastrointestinal hemorrhage in premature infants.Methods The prothrombin time（PT）,part-time activation thromboplastin(APTT）,thrombin time (TT),fibrinogen(Fib),D-dimer(D-D) in 132 hospitalized premature infants with gastrointestinal hemorrhage (observation group)and 156 non-hemorrhage premature infants (control group) were detected.The difference of coagulation function between two groups was compared.Results Compared with control group,the PT,APTT,and TT in observation group were significantly increased（P<0.01）,Fib was decreased（P<0.01） and D-D was obviously increased（P<0.01）.Conclusion The changes of coagulation function are closely related to gastrointestinal hemorrhage in premature infants and may be involved in the pathogenesis of gastrointestinal hemorrhage in premature infants.

Key words: premature infant；gastrointestinal hemorrhage；prothromin time；activated partial thromboplastin time；thrombin time；fibrinogen；D-dimer

中图分类号:

R725.732

吴伟晴, 吴本清, 李志光, 吴伟. 132例早产儿消化道出血及凝血功能变化分析[J]. J4, 2010, 36(4): 772-774.

WU Wei-Qing, WU Ben-Qing, LI Zhi-Guang, WU Wei. Analysis of coagulation function in 132 premature infants with gastrointestinal hemorrhage[J]. J4, 2010, 36(4): 772-774.