吉林大学学报(医学版) ›› 2013, Vol. 39 ›› Issue (2): 209-212.doi: 10.7694/jldxyxb20130204

• 基础研究 • 上一篇    下一篇

伏隔核脑深部电刺激对大鼠肥胖症的治疗作用

张弨1,张凯1,魏乃礼1,王尧1,胡文瀚2   

  1. (1.首都医科大学附属北京天坛医院神经外科,北京 100050;2.首都医科大学北京市神经外科研究所功能神经外科研究室,北京 100050)
  • 收稿日期:2012-10-31 出版日期:2013-03-28 发布日期:2012-03-28
  • 通讯作者: 张 凯 E-mail:(Tel:010-67096767,E-mail:zhangkai62035@sina.com)
  • 作者简介:张 弨(1985-),男,天津市人,在读医学博士,主要从事功能神经外科的基础与临床研究。
  • 基金资助:

    国家自然科学基金资助课题(30973085)

Deep brain stimulation of nucleus accumbens for treatment of obesity in rats

ZHANG Chao1,ZHANG Kai1,WEI Nai-li1,WANG Yao1,HU Wen-han2   

  1. (1. Department of Neurosurgery,Beijing Tiantan Hospital,Capital Medical University,Beijing 100050,China;2. Stereotactic and Functional Neurosurgery Laboratory,Beijing Neurosurgical Institute,Capital Medical University,Beijing 100050,China)
  • Received:2012-10-31 Online:2013-03-28 Published:2012-03-28

摘要: 目的:探索伏隔核(NAc)壳部脑深部电刺激术(DBS)对大鼠肥胖症的治疗作用,阐明DBS治疗肥胖症的可行性。 方法:30只大鼠随机分为DBS组和对照组,每组15只。2组大鼠均给予高脂饲料喂养并分别通过立体定向给予电极固定装置植入、电极植入,DBS组大鼠给予高频电刺激7 d,对照组不给予刺激,电极拔除后继续观察28 d。实验全程(57 d)每日监测大鼠体质量、摄食量和饮水量。综合比较2组大鼠体质量增长率、摄食量和饮水量变化。 结果:NAc壳电刺激第5天开始DBS组大鼠体质量增长率低于对照组(P<0.05),至实验结束时DBS组大鼠体质量平均增长幅度为10.2%,对照组为35.7%。电刺激期间DBS组大鼠摄食量低于对照组(P<0.05),刺激结束后2组大鼠摄食量差异无统计学意义(P>0.05)。2组大鼠饮水量在整个实验过程中差异无统计学意义(P>0.05)。 结论:NAc壳部可以作为DBS治疗大鼠肥胖症的理想靶点,一方面限制摄食行为,降低摄食量;另一方面可能通过其与能量平衡系统相互作用,增加大鼠能量消耗,减缓体质量增长。

关键词: 肥胖症, 脑深部电刺激, 伏隔核

Abstract: To explore the effect on obesity by deep brain stimulation(DBS) in the rat nucleus accumbens (NAc) shell,and to elucidate the feasibility of DBS for obesity treatment.
Methods 30 rats were randomly divided into DBS group(n=15) and control group(n=15).High fat feed was given from the beginning,and electrode fixing device and electrode were implanted stereotacticly.The rats in DBS group were given high frequency stimulation for 7 d,the rats in control group were not given stimulation.After electrode pulled-out,the rats in two groups were observed for another 28 d.In the whole experimental course (57 d),the body weight,food intake,and water intake were monitored every day.A comprehensive comparison of weight gain rate,food intake and water intake was conducted.Results  From the fifth day after NAc shell stimulation,the weight gain rates of  the rats in DBS group were lower than those in control group (P<0.05).At the end of the experiment,the weight gain rate reached to 10.2% and 35.7% in DBS group and control group.In the stimulation period,a food intake reduction was observed in DBS group(P<0.05).After  stimulation,the difference of food intake was no longer existed.The water intake during the whole experiment had no obvious changes in both groups(P>0.05).Conclusion NAc shell could be an ideal target for DBS in treatment of obesity in rats.On the one hand,it can limit feeding behavior,and reduce food intake;on the other hand,it may interact with energy homeostasis system,increase energy expenditure and decrease weight growth of rats.

Key words: obesity, deep brain stimulation, nucleus accumbens

中图分类号: 

  • R589.2