关键词: 顺铂, 宫颈肿瘤, 单纯放疗, 同步放化疗

Abstract: Objective To observe the curative effect of different doses of radiotherapy combined with cisplatin weekly therapy in the treatment of advanced cervi
cal cancer,and to explore better treatment options. Methods 135 cases of stage  ⅡB－ⅣA cervical cancer patients collected in Jilin Provincal Tumor Hospital
 from January 2007 to June 2008 met   the inclusion criteria were randomly divided into radiotherapy group(n=45,radiotherapy alone) and
concurrent chemoradiotherapy group(n=90),including 20 mg/m^-2 low dose group(n=45) and 40 mg/m^-2 standard dose group(n=45).
The 3-year survival rates and the incidence of related toxic reactions  in radiotherapy group and concurrent chemoradiotherapy group were compar
ed.At the same time the 3-year survival rates and the incidence of related  toxic reactions in 20  mg/m^-2 low dose group and 40  mg/m^-2 stand
ard dose group were compared.Results The median follow-up time was 42 (6-51) months.The 3-year survival rates  in  radiotherapy group and
  concurrent chemoradiotherapy  group  were 68.9% and 83.3%,the difference was statistically significant (χ2 = 3.858,P<0.05).The in
cidence of Ⅲ-Ⅳ acute toxic reactions in  radiotherapy  group was lower than that in  concurrent chemoradiotherapy group (χ2 = 4.072,P<0.05).The 3-year survival rates in  20 mg/m^-2 low dose group and 40  mg?m-2 standard dose group  were 82.2% and 84.4%,there was no significant difference between  two groups (χ² =0.090,P>0.05).The incidence of acute toxic reactions  in 20 mg/m^-2 low dose group was significantly lower than that in  40 mg?m-2 standard
 dose group(χ² =3.920,P<0.05).Conclusion Compared with radiotherapy alone,concurrent chemoradiotherapy can  significantly improve the efficacy of  ⅡB－ⅣA cervical carcinoma.In the concurrent chemoradiotherapy,compared with  40 mg?m-2 standard dose cisplatin,20 mg/m^-2 low dose cisplatin  doesn’t  reduce the effect of radiotherapy in patients,but  reduce the incidence of Ⅲ-Ⅳ stage acute toxic reactions  in patients.
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Key words: cisplatin, cervical neoplasms, simple radiotherapy,  ,  ,  , concurrent chemoradiotherapy