吉林大学学报(医学版)

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三参维心胶囊对心肌梗死诱导的心力衰竭大鼠心功能的改善作用

杨晓春，饶艳伟，张 勇，陆玉熊，苏 静，孙连坤   

  1. 吉林大学白求恩医学院病理生理学系，吉林 长春 130021
  • 收稿日期:2012-08-13 出版日期:2013-07-28 发布日期:2013-08-17
  • 通讯作者: 孙连坤（Tel:0431-85619402，E-mail:sunlk@jlu.edu.cn） E-mail:sunlk@jlu.edu.cn
  • 作者简介:杨晓春（1984-），男，陕西省凤翔县人，在读医学博士，主要从事病理生理学研究。
  • 基金资助:

    吉林省发改委基地建设项目资助课题（20091041）

Improvement effect of Sanshen Weixin Capsula on cardiac function in rats with heart failure induced by myocardial infarction

YANG Xiao-chun,RAO Yan-wei,ZHANG Yong,LU Yu-xiong,SU Jing,SUN Lian-kun   

  1. Department of Pathophysiology,Norman Bethune College of Medicine,Jilin University，Changchun 130021,China
  • Received:2012-08-13 Online:2013-07-28 Published:2013-08-17

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摘要：

目的: 探讨三参维心胶囊 (Sanshen) 对心力衰竭大鼠心功能的影响，为开发治疗心肌梗死诱导的心力衰竭的新药物提供依据。方法:结扎Wistar大鼠左冠状动脉前降支（LAD）,采用超声心动仪进行无创检测，确认大鼠发生心力衰竭之后将大鼠分为假手术（Sham）组(n=9)、模型（Model）组(n=8)、雷米普利（Ramipril）组(n=9)和Sanshen组(n=9)。模型建立1周后Ramipril组和Sanshen组大鼠分别给予Ramipril及Sanshen，给药5周后观察大鼠超声心动图和血流动力学变化，评估心脏脏器指数，采用显微摄影图像分析系统计算左心室梗死面积，观察组织形态学变化。结果: 超声心动图检测，与Model组比较，Sanshen组大鼠左室舒张末期内径（LVEDD）、左室收缩末期内径（LVESD）明显减小（P<0.01），左室射血分数（LVEF）、短轴缩短率（FS）明显升高（P<0.01）；血流动力学检测，Sanshen组大鼠左心室舒张末压（LVEDP）明显下降（P<0.05），左室收缩压（LVSP）明显升高 （P<0.05），左心室内压最大上升及下降速率（±dp/dtmax）明显升高（P<0.01）。与Model组比较，Sanshen组大鼠心室梗死面积明显减少（P<0.05），心脏脏器指数降低（P<0.05）。形态学观察，与Model组比较，Sanshen组大鼠心室心肌细胞排列整齐，间质水肿明显减轻，间质中结缔组织增生和炎性细胞浸润减少，心肌纤维未见明显增粗。结论: Sanshen具有改善心肌梗死导致的心力衰竭大鼠心功能的作用，提示Sanshen可能成为治疗心力衰竭的新药。

关键词: 三参维心胶囊, 心力衰竭, 超声心动图, 血流动力学

Abstract:

Abstract:Objective To study the effect of Sanshen Weixin Capsula (Sanshen) on cardiac function in rats with heart failure induced by myocardial infarction,and  to provide basis for developing the new drugs to treat heart failure inducedby myocardial infarction. Methods The heart failure model was induced by myocardial infarction in rats with left anterior descending coronary (LAD) occulusion.The Wistar rats with heart failure were divided into four groups after detecting cardiac function by  echocardiography: sham operation group(n=9),heart failure model group(n=8),ramipril group(n=9) andSanshen group(n=9).After 1 week,the rats in sham operation group and model group were treated  with distilled water,and the rats in Ramipril group and Sanshen group were treated with ramipril and Sanshen,respectively.After 5 weeks,the changes of echocardiography and hemodynamics were observed,and the heartorgan index and infarction area were evaluated,and the histomorphogical changes were observed.Results Compared with model group,the left ventricular end-diastolic dimension (LVEDD) and the left ventricular end-systolic dimension (LVESD)in Sanshen group  were decreased significantly(P<0.01)；the left ventricular ejection fraction（LVEF） and the franctional shortening（FS）were increased significantly(P<0.01).Compared with model group,the left ventricular end diastolic pressu(LVEDP) in Sanshen group  was decreased significantly(P<0.05)；the left ventricular systolic pressure（LVSP） and the maximal ventricular pressure rise ratio during systolic period/decrease ratio during diastolic period（±dp/dtmax） were increased significantly (P<0.05 or P<0.01).Compared with model group,the infraction area of left ventricle and heart organ index in Sanshen group were decreased significantly (P<0.05).Compared with model group,the ventricular myocardial cells in Sanshen group arranged in neat rows,the interstitial edema was significantly reduced,the interstitial connective tissue proliferation and inflammatory cell infiltration were decreased,and the myocardial fibers were not significantly enlarged.Conclusion  Sanshen can improve cardiac function in the rats with heart failure induced by myocardial infarction，suggestting that it can be used as a new drug for treatment of heart failure.

Key words: Sanshen Weixin Capsula, heart failure, echocardiography, hemodynamics

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