非小细胞肺癌患者血清叶酸、同型半胱氨酸和维生素B12的检测及其临床意义

doi:10.13481/j.1671-587x.20150626

摘要/Abstract

摘要：

目的:检测非小细胞肺癌(NSCLC)患者血清中叶酸、同型半胱氨酸(Hcy)和维生素B₁₂水平,阐明叶酸、Hcy和维生素B₁₂水平用于NSCLC诊断及预后评估的临床意义。方法:选取35例NSCLC患者作为NSCLC组,另选30名健康体检者作为对照组,排除高血压、贫血和家族病史等相关影响因素,采用循环酶法和电化学发光法检测2组受试者血清叶酸、Hcy及维生素B₁₂水平。采用Pearson检验分析2组受试者血清中叶酸、Hcy及维生素B₁₂水平的相关性。结果:NSCLC组患者Hcy水平明显高于对照组(P<0.01);NSCLC组患者叶酸水平明显低于对照组(P<0.01);而2组间维生素B₁₂水平比较差异无统计学意义(P>0.05)。Pearson相关分析,NSCLC组患者血清Hcy水平与叶酸水平呈负相关关系(r=-0.505,P=0.002),与维生素B₁₂水平无关联(r =-0.084,P=0.633),叶酸水平与维生素B₁₂水平无关联(r=-0.039,P=0.826)。结论:NSCLC患者血清Hcy水平显著升高,其对NSCLC患者诊断及评估预后有预测价值。

关键词: 非小细胞肺癌, 叶酸, 同型半胱氨酸, 维生素B₁₂

Abstract:

Objective To detect the serum levels of folate, homocysteine (Hcy) and vitamin B₁₂ in the patients with non-small cell lung cancer(NSCLC), and to clarify the clinical significance of folate,Hcy and vitamin B₁₂ in the diagnosis and prognosis assessment of NSCLC. Methods 35 patients with NSCLC were chosen as NSCLC group,and 30 healthy people were selected as control group, excluding hypertension, anemia, family disease history and other related factors. The expression levels of serum folate,Hcy and vitamin B₁₂ were examined by circulating enzymatic method and electrochemical luminescence method.The correlations between the levels of serum folate,Hcy and vitamin B₁₂ of the objects in two groups were analyzed by Pearson test. Results The serum Hcy level of the patients in NSCLC group was significantly higher than that in control group(P<0.01).The serum folate level of the patients in NSCLC group was significantly lower than that in control group(P<0.01),while there was no significant difference in vitamin B₁₂ levels between two groups(P>0.05).The serum Hcy level was negatively correlated with folate level(r=-0.505,P=0.002), but was not correlated with vitamin B₁₂(r =-0.084,P=0.633). The serum folate level was not correlated with vitamin B₁₂(r=-0.039,P=0.826). Conclusion The serum Hcy level of NSCLC patient is significantly increased and it has diagnostic and prognostic values in the NSCLC patients.

Key words: non-small cell lung cancer, folate, homocysteine, vitamin B₁₂

中图分类号:

R446

于秀艳, 王文龙, 吴雪峰, 刘晓峰. 非小细胞肺癌患者血清叶酸、同型半胱氨酸和维生素B₁₂的检测及其临床意义[J]. 吉林大学学报(医学版), 2015, 41(06): 1235-1238.

YU Xiuyan, WANG Wenlong, WU Xuefeng, LIU Xiaofeng. Detection of serum folate, homocysteine and vitamin B₁₂ in patients with non-smallcell lung cancer and its clinical significance[J]. Journal of Jilin University Medicine Edition, 2015, 41(06): 1235-1238.

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非小细胞肺癌患者血清叶酸、同型半胱氨酸和维生素B₁₂的检测及其临床意义

Detection of serum folate, homocysteine and vitamin B₁₂ in patients with non-smallcell lung cancer and its clinical significance

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