关键词: 种植体周围炎, 中药清热消炎固齿缓释剂, 龈下喷砂, 牙周探诊深度, 改良龈沟出血指数

Abstract: Objective: To explore the clinical efficacy of Qingre Xiaoyan Guchi Sustained Release Preparation combined with subgingival sandblasting in the treatment of peri-implantitis, and to clarify its mechanism in the treatment of peri-implantitis. Methods: Seventy-two patients with peri-implantitis were selected and divided into control group and Chinese medicine group according to the time of consultation (n=36). Both groups of patients were treated with basic periodontal treatment by the first doctor;the patients in control group received supragingival scaling treatment and subgingival sandblasting, and the patients in Chinese medicine group received supragingival treatment, subgingival curettage, and subgingival sandblasting. The implant periodontal pockets of the patients in two groups were rinsed and placed with drugs by the second doctor.The patients in Chinese medicine group were rinsed with 0.9% sodium chloride injection and received Qingre Xiaoyan Guchi Sustained Release Preparation in the pockets around the implants;and 3% hydrogen peroxide + 0.9% sodium chloride injection was used to rinse the pockets around the implants in control group. The periodontal indexes,including modified plaque index(mPLI),periodontal probing depth(PPD), modified sulcular bleeding index(mSBI)of the patients' teeth in two groups were recorded before treatment and after 1 course of treatment(4 weeks as a course of treatment) by the third doctor,and the implant gingival crevicular fluid (PISF) quality and the interleukin-1β(IL-1β) levels in PISF of the patients in two groups were detected. Results: There were no significant differences in the PPD, mSBI, mPLI, PISF, and IL-1β in PISF of the patients between two groups before treatment (P>0.05). Compared with before treatment,after intervention of different treatment methods,the mPLI,PPD,and mSBI of the patients in two groups were decreased (P<0.05).Compared with control group. the mSBI, mPLI, and PPD of the patients in Chinese medicine group after treatment were significantly reduced(P<0.05),and the PISF quality and the IL-1β levels in PISF were also significantly reduced (P<0.05). Conclusion: Compared with traditional mechanical therapy combined with hydrogen peroxide and saline irrigation, the use of Qingre Xiaoyan Guchi Sustained Release Preparation combined with subgingival sandblasting is more effective in treating peri-implantitis,which can significantly reduce PPD, mSBI, mPLI, PISF quality and IL-1β level, and the clinical symptoms are alleviated after treatment.

Key words: peri-implantitis, Qingre Xiaoyan Guchi Sustained Release Preparation, subgingival sandblasting, periodontal probing depth, modified sulcular bleeding index